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Overview

Acids substance concepts should be modeled with a structural parent concept.

Salts should be modeled with a conjugate base as parent (if one exists, otherwise they are modeled with a structural parent). Salts may have an Is modification of (attribute) relationship to the conjugate acid where a specific use case is identified. See examples of such use cases in the "Concepts Representing a Substance or its Modifications" section of this Editorial Guide.

Conjugate base concepts ( e.g. valproate, pamidronate, etidronate) should only be created where a specific use case is identified for example when required to support the definition of other concepts in the terminology.

Conjugate bases should be created as separate concepts - not added as synonyms to the corresponding acid concept.

New instances of substance concepts containing the word "salt" will not be added. The existing concepts will be reviewed and if possible will be replaced by equivalent compounds.

Modeling

Parent concept

Most distal appropriate descendant of 312413002 |Substance categorized structurally (substance)|

Semantic tag

(substance)

Definition status

Primitive

Attribute:

Is Modification of

  • Range  <105590001 |Substance (substance)|
  • Cardinality: 0..1
  • Used to identify the conjugate acid

Attribute:

Has disposition

  • Range: <726711005 |Disposition (disposition)|
    • NOTE: While the allowed range is broader, substance concepts should only use descendants of the concept 726711005 |Disposition (disposition)| as the attribute value.
  • Cardinality: 0..1

Naming Guidelines

Where INN names exist these should be used for the FSN and PT

FSN

Pattern:

  • X sulfate (substance)
  • X pamidronate (substance)

For example,

      • Copper sulfate (substance)
      • Disodium pamidronate (substance)

      • Etidronate (substance)

Exception:

  • Valproate sodium (substance)

Preferred Term

Pattern:

    • X sulfate
    • X pamidronate


For example,

      • Copper sulfate
      • Pamidronate monosodium
      • Etidronate

Exception:

  • Valproate sodium

Synonyms

Pattern: Pamidronate X

For example,

      • Pamidronate monosodium
      • Valproate sodium

Exemplar

The following illustrates the stated and inferred views.

   




The following illustrates the stated and inferred views.



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