Allergies, Hypersensitivity and Intolerance Clinical Reference Group meeting agenda for December 14, 2017

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Item	Description	Owner	Item	Discussion/Actions
1	Welcome and role call	BGO, all
2	Review of allergen classes and questionable allergen groupers in allergy to substance hierarchy	BGO	I am posting 2 files created by the allergy update project for review by our group. The first file contains a list of allergen/pseudoallergen classes. We wish to solicit input from this group as to whether these need to be retained in the revisions to the substance hierarchy. Note that the use of allergen classes (as opposed to just substances) has been used only infrequently for the modeling of allergies. The second file lists all of the descendants of allergic disposition and some questionable groupers which we need to determine clinical relevance for in order to guide the modeling of the causative agents in the substance hierachy	Allergen Groupers in Substance Hierarchy.xlsx Allergic disposition descendants.xlsx
3	Updates to model of allergic disease	BGO	Treat allergic diseases as pathological structures and model with a role group containing: associated morphology+finding site+causative agent+pathological process=allergic process Approval to initially add additional allergic processes of IgE-mediated allergic process, non-IgE mediated allergic process and contact hypersensitivity process Bruce Goldberg to test addition of additional pathological processes corresponding to Gell and Coomb's hypersensitivity mechanisms in order to full define allergic disorders by mechanism
4	Adjourn	BGO	AOB