Descriptions:
| Term | description type | Language/acceptability | Langauge/acceptability | Case significance |
|---|---|---|---|---|
Adverse reaction caused by [substance] (disorder) Is template for 62014003 |Adverse reaction caused by drug (disorder)| managed as part of this template or separately? It is currently a subtype of Adverse reaction caused by 62014003 |Adverse reaction caused by drug (disorder)|. It would be better if they were together since part of the guidelines will be directed towards helping authors determine if concepts should be modeled with a substance vs. product concept. Existing content has two different terming patterns - need agreement on which is preferred:
| FSN | us:P | gb:P | ci |
Adverse reaction caused by [substance] See FSN re: existing patterns | SYN | us:P | gb:P | ci |
Concept model:
| Attribute Cardinality | Attribute | Value | role group number | Role group cardinality |
|---|---|---|---|---|
| 1..1 | 0 | N/A | ||
| 1..1 | [substance] [agent] << 105590001 |Substance (substance)| OR << 373873005 |Pharmaceutical / biologic product (product)| | 1 | 1..1 |
Definition status:
900000000000073002 |Defined (core metadata concept)|
Applies to:
<<
282100009 |Adverse reaction caused by substance (disorder)|
Editorial guidelines for selection of Causative agent attribute value:
| Hierarchy | Concept type | Allowed | Exception | Example - update with final decision re: terming |
|---|---|---|---|---|
| Substance | Base | yes | none | 292350008 |Alprazolam adverse reaction (disorder)| |
| Substance | Disposition grouper | yes | none | 292736001 |Opioid antagonist adverse reaction (disorder)| |
| Substance | Modification | no, unless explicitly documented as exception | TBD | TBD |
| Substance | Structure grouper | yes | none | 218638005 |Adverse reaction caused by hydantoin derivative (disorder)| |
| Product | Disposition grouper | no | none | n/a |
| Product | Role grouper | yes | none | TBD |
| Product | Structure grouper | no | none | n/a |
| Product | Medicinal product-containing | TBD | TBD | TBD |
| Product | Medicinal product-only | TBD | TBD | TBD |
| Product | Medicinal product form-containing | TBD | TBD | TBD |
| Product | Medicinal product form-only | TBD | TBD | TBD |
| Product | Clinical drug | no | none | n/a |
Rules for description generation:
- For the FSN, align terming and case sensitivity with the FSN for the Substance concept that is selected as the attribute value, excluding the semantic tag.
- For the PT, align terming and case sensitivity with the US and GB PTs for the Substance concept that is selected as the attribute value.
- In cases where neither the US or GB PT matches the FSN, excluding the semantic tag, a synonym corresponding to the FSN is required unless explicitly identified as an exception.
- Additional synonyms are not allowed unless explicitly identified as an exception.