Substances specifying a source or origin

Overview

• A recombinant (A new entity e.g., gene, protein, cell, or individual that results from genetic recombination) or synthetic/semi-synthetic substance (of, relating to, or produced by chemical or biochemical synthesis; especially: produced artificially) is similar in structure (but not identical to the naturally occurring substance). It should be created as a sibling of the naturally occurring substance.

• A substance that is part of (e.g. dander) or is derived from (e.g. Insulin) an organism (human or non-human) is identical and should be created as a child of the naturally occurring substance.

Modeling

Naming Guidelines

“Recombinant”, “Synthetic”, or “Semi-synthetic” should precede the name of the substance

The source organism name should precede the name of the substance

• An exception to this rule is the naming of DNA, RNA, rRNA, antibody, Immunoglobulin, and antigen of organisms, which should follow the guideline specified for antibodies and antigens

• For some non-human sources, there are different ways of referring to the source organism:

  • The common name of the organism e.g. pig, cow, horse, mouse, sheep

    • The common name of an organism is used when referring to a part of the organism or to non-meat products
      • E.g. Pig epithelium, Cow milk

  • An adjective referring to the organism, e.g. porcine, bovine, equine, murine, ovine

    • The adjective is usually used when referring to a substance extracted from the organism
      • E.g. Bovine growth hormone (substance), Porcine calcitonin (substance)
  • The adjective is commonly used in referring to the organism hosting a virus, but there are exceptions. In general, proper name of organism such as virus name should be preserved as it is (including the case sensitivity):
    • Ribonucleic acid of Bovine leukemia virus (substance)
    • Immunoglobulin G antibody to Eastern equine encephalitis virus (substance)
    • Antigen of Nairobi sheep disease virus (substance)

Additional adjectives (such as labeled, Iodinated) should proceed the name of source organism

For example,

• Lente human insulin (substance)

• Iodinated (125-I) human serum albumin (substance)

If a concept includes “recombinant” or “synthetic” as well as a source organism, “recombinant” or “synthetic” should precede the source organism name

For example,

• Recombinant bovine growth hormone (substance)

Exemplar

Exemplar

Stated view of 411973001 |Bovine thrombin (substance)|