Overview
A recombinant (A new entity e.g., gene, protein, cell, or individual that results from genetic recombination) or synthetic/semi-synthetic substance (of, relating to, or produced by chemical or biochemical synthesis; especially: produced artificially) is similar in structure (but not identical to the naturally occurring substance). It should be created as a sibling of the naturally occurring substance.
A substance that is part of (e.g. dander) or is derived from (e.g. Insulin) an organism (human or non-human) is identical and should be created as a child of the naturally occurring substance.
Modeling
Parent concept | Most distal appropriate descendant of 105590001 |Substance (substance)| |
Semantic tag | (substance) |
Definition status | Primitive |
Attribute | 738774007 |Is modification of (attribute)| as applicable 726542003 |Has disposition (attribute)| as appropriate |
Naming
“Recombinant”, “Synthetic”, or “Semi-synthetic” should precede the name of the substance
The source organism name should precede the name of the substance
An exception to this rule is the naming of DNA, RNA, rRNA, antibody, Immunoglobulin, and antigen of organisms, which should follow the guideline specified for antibodies and antigens
For some non-human sources, there are different ways of referring to the source organism:
The common name of the organism e.g. pig, cow, horse, mouse, sheep
- The common name of an organism is used when referring to a part of the organism or to non-meat products
- E.g. Pig epithelium, Cow milk
- The common name of an organism is used when referring to a part of the organism or to non-meat products
An adjective referring to the organism, e.g. porcine, bovine, equine, murine, ovine
- The adjective is usually used when referring to a substance extracted from the organism
- E.g. Bovine growth hormone (substance), Porcine calcitonin (substance)
- The adjective is usually used when referring to a substance extracted from the organism
- The adjective is commonly used in referring to the organism hosting a virus, but there are exceptions. In general, proper name of organism such as virus name should be preserved as it is (including the case sensitivity):
- Ribonucleic acid of Bovine leukemia virus (substance)
- Immunoglobulin G antibody to Eastern equine encephalitis virus (substance)
- Antigen of Nairobi sheep disease virus (substance)
Additional adjectives (such as labeled, Iodinated) should proceed the name of source organism
For example,
Lente human insulin (substance)
Iodinated (125-I) human serum albumin (substance)
If a concept includes “recombinant” or “synthetic” as well as a source organism, “recombinant” or “synthetic” should precede the source organism name
For example,
Recombinant bovine growth hormone (substance)
FSN | Pattern:
For example,
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Preferred Term | Pattern:
For example,
|
Exception | The naming of DNA, RNA, rRNA, antibody, Immunoglobulin, and antigen of organisms should follow the specific guideline for this type of substances. |
Exemplar
Exemplar
Stated view of 411973001 |Bovine thrombin (substance)|
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