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Descriptions:

Termdescription typeLanguage/acceptabilityLangauge/acceptabilityCase significance

Adverse [finding site] reaction caused by [agent] (disorder)

Existing content has two different terming patterns - need agreement on which is preferred:

  • 292350008 |Alprazolam adverse reaction (disorder)|
  • 218620007 |Adverse reaction caused by naproxen (disorder)|
FSNus:Pgb:Pci

Adverse reaction caused by [agent]

See FSN re: existing patterns

SYNus:Pgb:Pci


Concept model:

Attribute CardinalityAttributeValuerole group numberRole group cardinality
1..1

116680003 |Is a (attribute)|

281647001 |Adverse reaction (disorder)|

0N/A
1..1

246075003 |Causative agent (attribute)|


[agent] <<  105590001 |Substance (substance)|  OR <<  373873005 |Pharmaceutical / biologic product (product)|




1




1..1

0..1

363698007 |Finding site (attribute)|

[finding site] < 123037004 |Body structure (body structure)|

Definition status:  


900000000000073002 |Defined (core metadata concept)|

Template Language

281647001 |Adverse reaction (disorder)|: [[~1..1]] { [[~0..1]] 363698007 |Finding site (attribute)| = [[+id(< 123037004 |Body structure (body structure)|) @site]], [[~1..1]] 246075003 |Causative agent (attribute)| = [[+id( << 105590001 |Substance (substance)| OR << 373873005 |Pharmaceutical / biologic product (product)|) @agent]] }

Applies to:

<<  282100009 |Adverse reaction caused by substance (disorder)|

Editorial guidelines for selection of Causative agent attribute value:

HierarchyConcept typeAllowedExceptionExamples and Notes - update examples to reflect final decision re: terming pattern
SubstanceBaseyesnone

Example:

  • 292350008 |Alprazolam adverse reaction (disorder)|

Expected classification results:

SubstanceModificationnoTBD

Example:

Expected classification results:

SubstanceDisposition grouperyesnone

Example:

  • 292736001 |Opioid antagonist adverse reaction (disorder)|

Expected classification results:

ProductDisposition groupernononeDisposition groupers in the Product hierarchy should only exist as SD concepts with a corresponding concept in the Substance hierarchy; the corresponding concept in the Substance hierarchy should be used for modeling in this subhierarchy.
SubstanceRole groupernononeRole groupers in the Substance hierarchy will be inactivated in a future release and should not be used for modeling in this subhierarchy.
ProductRole grouperyesnone

Example:

Expected classification results:

TBD if there are any restrictions on which product roles can be used in modeling in this subhierarchy

SubstanceStructure grouperyesnone

Example:

  • 218638005 |Adverse reaction caused by hydantoin derivative (disorder)|

Expected classification:

ProductStructure groupernononeStructure groupers in the Product hierarchy should only exist as SD concepts with a corresponding concept in the Substance hierarchy; the corresponding concept in the Substance hierarchy should be used for modeling in this subhierarchy.
Product or SubstanceBody system groupernonone

Body system groupers in both the Substance and Product hierarchies will be inactivated in a future release and should no longer be used for modeling in this hierarchy.

Example:

  • 293416008 |Drug groups primarily affecting cardiovascular system adverse reaction (disorder)|
  • 292670005 |Drug groups primarily affecting musculoskeletal system adverse reaction (disorder)|
ProductMedicinal product-containingyesnone

Example:

  • 292984002 Ampicillin and cloxacillin adverse reaction (disorder)
  • 292267003 Benserazide + levodopa adverse reaction (disorder)

Expected classification results: NEEDS INTERNAL AGREEMENT

  • 292984002 Ampicillin and cloxacillin adverse reaction (disorder) will be modeled with Causative agent = 346320003 |Product containing ampicillin and cloxacillin (medicinal product)| and will have the the following inferred parents:
    • 292968003 |Ampicillin adverse reaction (disorder)| with Causative agent = 387170002 |Ampicillin (substance)|
    • 292963007 |Cloxacillin adverse reaction (disorder)| with Causative agent = 373276005 |Cloxacillin (substance)|
  • 292267003 Benserazide + levodopa adverse reaction (disorder) will be modeled with Causative agent = 418467003 |Product containing benserazide and levodopa (medicinal product)| and will have the following inferred parents:
    • 292266007 |Levodopa adverse reaction (disorder)| with Causative agent = 387086006 |Levodopa (substance)|
    • Note: There is not an existing concept for Adverse reaction to benserazide.
ProductMedicinal product-onlynononeMedicinal product-containing concepts can be used for modeling in this subhierarchy.
ProductMedicinal product form-containingyesnone

Example:

Expected classification results:

ProductMedicinal product form-onlynononeMedicinal product form-containing concepts can be used for modeling in this subhierarchy.
ProductClinical drugnononen/a


Rules for description generation:

  1. For the FSN, align terming and case sensitivity with the FSN for the concept that is selected as the attribute value, excluding the semantic tag. 
  2. For the PT, align terming and case sensitivity with the US and GB PT for the concept that is selected as the attribute value.
  3. In cases where neither the US or GB PT matches the FSN, excluding the semantic tag, a synonym corresponding to the FSN is required unless explicitly identified as an exception.
  4. Additional synonyms are not allowed unless explicitly identified as an exception.

JIRA ticket for implementation:


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