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Descriptions:
Term | description type | Language/acceptability | LangaugeLanguage/acceptability | Case significance |
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Adverse reaction caused by [substance[finding site] reaction to [agent] (disorder) Is template for 62014003 |Adverse reaction caused by drug (disorder)| managed as part of this template or separately? It would be better if they were together since part of the guidelines will be directed towards helping authors determine if concepts should be modeled with a substance vs. product concept. Existing content has two different terming patterns - need agreement on which is preferred:
| FSN | us:P | gb:P | ci |
Adverse reaction caused by [substance] See FSN re: existing patterns [finding site] reaction to [agent] | SYN | us:P | gb:P | ci |
Concept model:
Attribute Cardinality | Attribute | Valuerole group number | Role group cardinality | |||||||
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1..1 |
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| N/A | |||||||
1..1 |
| [substance]
| <105590001
| 1..1 | 1||||||
0..1 |
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Definition status:
...
Scg expression |
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900000000000073002|Defined (core metadata concept)| |
Template Language
281647001 |Adverse reaction (disorder)|: [[~1..1]] { [[~0..1]] 363698007 |Finding site (attribute)| = [[+id(< 123037004 |Body structure (body structure)|) @site]], [[~1..1]] 246075003 |Causative agent (attribute)| = [[+id( << 105590001 |Substance (substance)| OR << 373873005 |Pharmaceutical / biologic product (product)| OR << 260787004 |Physical object (physical object)| OR << 78621006 |Physical force (physical force)|) @agent]] }
Applies to:
Scg expression |
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<< 282100009 |Adverse reaction caused by substance (disorder)| MINUS <<418634005 |Allergic reaction caused by substance (disorder)| |
Editorial guidelines for selection of Causative agent attribute value:
The following editorial guidelines apply to concepts in the International Release; editorial guidelines for concepts in national extensions may vary.
Causative agent |
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type | Allowed |
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Examples and Notes (Note: Examples are existing concepts and may not reflect the terming patterns described in the template.) | ||
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Substance base | yes | Adverse reaction concepts representing a substance base should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Example:
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Expected classification:
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Substance modification | no, unless |
documented as exception |
Adverse reaction concepts representing a substance modification should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Concepts representing substance modifications are exceptions and may be included if the adverse reaction profile is significantly different from the substance base. Exception examples:
Example:
Expected classification:
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Multiple substance | yes | Adverse reaction concepts representing multiple substances should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|; preferentially modeling with the base rather than a modification unless the adverse reaction profile is significantly different from the substance base. Example:
Expected classification (Agreed 21-Jan-2020):
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Disposition grouper | yes | Adverse reaction concepts representing a disposition grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Example:
Expected classification results:
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Role grouper | yes | Adverse reaction concepts representing a role grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Note that role groupers will be transitioned to the 763158003 |Medicinal product (product)| hierarchy in a future release. Example:
Expected classification results (Agreed 21-Jan-2020):
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Structure grouper | yes | Adverse reaction concepts representing a structure grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Example:
Expected classification (Agreed 21-Jan-2020):
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Descendant of 373873005 |Pharmaceutical / biologic product (product)| | no, unless documented as exception | Exceptions: None identified |
The following types of groupers are out of scope; existing concepts have been inactivated or will be addressed in future release:
- Groupers based on more than one role (e.g. 292722006 |Chelating agents and antidotes adverse reaction (disorder)|)
- Groupers based on body system or intended site or route of administration (e.g. 292548001 |Drug groups primarily affecting respiratory system adverse reaction (disorder)|) or 417895009 |Topical agent adverse reaction (disorder)|)
- Groupers based on disposition, role, or structure combined with an individual substance (e.g. 287177000 |Sulfonamide/trimethoprim reaction (disorder)| or 292513008 |Methyldopa and diuretic adverse reaction (disorder)|)
- Groupers based on "combined" or "compound" substances (e.g. 292983008 |Combined penicillin preparation adverse reaction (disorder)| or 293358005 |Compound iron preparations adverse reaction (disorder)|)
- Groupers based on disposition or structure combined with intended site or route of administration (e.g. 433494006 |Adverse effect of oral diphosphonate (disorder)|)
- Groupers based on disposition combined with role (e.g. 292265006 |Dopaminergic drug used in parkinsonism adverse reaction (disorder)|)
Rules for description generation:
- For the FSN, align terming and case sensitivity with the FSN for the Substance concept that is selected as the attribute value, excluding the semantic tag.
- For the PT, align terming and case sensitivity with the US and GB PTs PT for the Substance concept that is selected as the attribute value.
- In cases where neither the US or GB PT matches the FSN, excluding the semantic tag, a synonym corresponding to the FSN is required unless explicitly identified as an exception.
- Additional synonyms "[agent] adverse reaction" should be added. Other synonyms are not allowed unless explicitly identified as an exception.