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Descriptions:
Term | description type | Language/acceptability | LangaugeLanguage/acceptability | Case significance |
---|---|---|---|---|
Adverse [finding site] reaction to [agent] (disorder) | FSN | us:P | gb:P | ci |
Adverse [finding site] reaction to [agent] | SYN | us:P | gb:P | ci |
Concept model:
Attribute Cardinality | Attribute | Value | role group number | Role group cardinality | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
1..1 |
|
| 0 | N/A | |||||||
1..1 |
|
| )| OR << 260787004|Physical object (physical object)| OR << 78621006|Physical force (physical force
| 11..1 | |||||||
0..1 |
|
|
Definition status:
Scg expression |
---|
900000000000073002|Defined (core metadata concept)| |
Template Language
281647001 |Adverse reaction (disorder)|: [[~1..1]] { [[~0..1]] 363698007 |Finding site (attribute)| = [[+id(< 123037004 |Body structure (body structure)|) @site]], [[~1..1]] 246075003 |Causative agent (attribute)| = [[+id( << 105590001 |Substance (substance)| OR << 373873005 |Pharmaceutical / biologic product (product)| OR << 260787004 |Physical object (physical object)| OR << 78621006 |Physical force (physical force)|) @agent]] }
Applies to:
Scg expression |
---|
<< 282100009 |Adverse reaction caused by substance (disorder)| MINUS <<418634005 |Allergic reaction caused by substance (disorder)| |
Editorial guidelines for selection of Causative agent attribute value:
The following editorial guidelines apply to concepts in the International Release; editorial guidelines for concepts in national extensions may vary.
Causative agent |
---|
type | Allowed |
---|
Examples and Notes (Note: Examples are existing concepts and may not reflect the terming patterns described in the template.) | |
---|---|
Substance |
base | yes |
Adverse reaction concepts representing a substance base should |
be modeled using a Causative agent that is a descendant of |
105590001 |Substance (substance)| |
. Example: |
Expected classification |
:
|
Substance |
modification | no, unless documented as exception |
Adverse reaction concepts representing a substance modification should |
Example:
- NEED EXAMPLE WHERE SUBSTANCE MODIFICATION WILL BE USED INSTEAD OF PRODUCT
be modeled using a Causative agent that is a descendant of |
105590001 |Substance (substance)|. Concepts representing substance modifications are exceptions and may be included if the adverse reaction profile is significantly different from the substance base. Exception examples:
Example:
Expected classification |
:
|
| ||
Multiple substance | yes | Adverse reaction concepts representing multiple substances should |
be modeled using a Causative agent that is a descendant of |
Example:
- NEED EXAMPLE WHERE SUBSTANCE WILL BE USED INSTEAD OF PRODUCT
105590001 |Substance (substance)|; preferentially modeling with the base rather than a modification unless the adverse reaction profile is significantly different from the substance base. Example:
Expected classification |
(Agreed 21-Jan-2020):
|
|
Disposition grouper |
yes | Adverse reaction concepts representing a disposition grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Example:
Expected classification results:
| |
Role grouper | yes | Adverse reaction concepts representing a role grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Note that role groupers will be transitioned to the 763158003 |Medicinal product (product)| hierarchy in a future release. Example:
Expected classification results (Agreed 21-Jan-2020):
|
Structure grouper | yes | Adverse reaction concepts representing a structure grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. |
Role groupers in the Substance hierarchy will be inactivated in a future release and should not be used for modeling in this subhierarchy. (Agreed 21-Jan-2020)
Insert examples of role grouper.
Example:
Expected classification results:
TBD if there are any restrictions on which product roles can be used in modeling in this subhierarchy
No use case has been identified for use of this concept type for modeling in this subhierarchy. Existing groupers representing role + structure will be inactivated and replaced with structure grouper. (Agreed 11-Feb-2020)
Example:
- 292320000 |Barbiturate antiepileptic adverse reaction (disorder)|
- 292337007 |Barbiturate sedative adverse reaction (disorder)|
- 292916005 |Benzimidazole anthelmintic adverse reaction (disorder)|
- 292343009 |Benzodiazepine sedative adverse reaction (disorder)|
Example:
Expected classification (Agreed 21-Jan-2020):
|
Body system groupers in both the Substance and Product hierarchies will be inactivated in a future release and should no longer be used for modeling in this hierarchy. (Agreed 21-Jan-2020)
Example:
293416008 |Drug groups primarily affecting cardiovascular systemDescendant of 373873005 |Pharmaceutical / biologic product (product)| | no, unless documented as exception | Exceptions: None identified |
The following types of groupers are out of scope; existing concepts have been inactivated or will be addressed in future release:
- Groupers based on more than one role (e.g. 292722006 |Chelating agents and antidotes adverse reaction (disorder)|
...
- )
- Groupers based on body system or intended site or route of administration (e.g. 292548001 |Drug groups primarily affecting
...
- respiratory system adverse reaction (disorder)|
...
Example:
...
- ) or 417895009 |Topical agent adverse reaction (disorder)
...
Expected classification results: Needs input from Drugs WG - see DRUGS-865
...
- |
...
- )
...
- 292968003 |Ampicillin adverse reaction (disorder)| with Causative agent = 387170002 |Ampicillin (substance)|
- 292963007 |Cloxacillin adverse reaction (disorder)| with Causative agent = 373276005 |Cloxacillin (substance)|
- Groupers based on disposition, role, or structure combined with an individual substance (e.g. 287177000 |Sulfonamide/trimethoprim reaction (disorder)| or 292513008 |Methyldopa and diuretic
...
- adverse reaction (disorder)|
...
- )
...
Example:
- Groupers based on "combined" or "compound" substances (e.g. 292983008 |Combined penicillin preparation
...
- adverse reaction (disorder)
...
- | or 293358005 |Compound iron preparations adverse reaction (disorder)
...
Expected classification results: Needs input from Drugs WG - see DRUGS-866
...
- |
...
- )
...
- 293542006 |Glyceryl trinitrate adverse reaction (disorder)| with Causative agent = 387404004 |Glyceryl trinitrate (substance)|
...
- 293542006 |Glyceryl trinitrate adverse reaction (disorder)| with Causative agent = 387404004 |Glyceryl trinitrate (substance)|
...
- 293542006 |Glyceryl trinitrate adverse reaction (disorder)| with Causative agent = 387404004 |Glyceryl trinitrate (substance)|
- Groupers based on disposition or structure combined with intended site or route of administration (e.g. 433494006 |Adverse effect of oral diphosphonate (disorder)|)
- Groupers based on disposition combined with role (e.g. 292265006 |Dopaminergic drug used in parkinsonism adverse reaction (disorder)|)
...
No use case has been identified for use of this concept type for modeling in this subhierarchy.
...
Rules for description generation:
- For the FSN, align terming and case sensitivity with the FSN for the concept that is selected as the attribute value, excluding the semantic tag.
- For the PT, align terming and case sensitivity with the US and GB PT for the concept that is selected as the attribute value.
- In cases where neither the US or GB PT matches the FSN, excluding the semantic tag, a synonym corresponding to the FSN is required unless explicitly identified as an exception.
- Additional synonyms "[agent] adverse reaction" should be added. Other synonyms are not allowed unless explicitly identified as an exception.