Page properties | ||||||
---|---|---|---|---|---|---|
|
Descriptions:
Term | description type | Language/acceptability | LangaugeLanguage/acceptability | Case significance |
---|---|---|---|---|
Adverse [finding site] reaction to [agent] (disorder) | FSN | us:P | gb:P | ci |
Adverse [finding site] reaction to [agent] | SYN | us:P | gb:P | ci |
Concept model:
Attribute Cardinality | Attribute | Valuerole group number | Role group cardinality | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
1..1 |
|
| 0 | N/A | |||||||
1..1 |
|
| )| OR << 260787004|Physical object (physical object)| OR << 78621006|Physical force (physical force
| 11..1 | |||||||
0..1 |
|
|
Definition status:
Scg expression |
---|
900000000000073002|Defined (core metadata concept)| |
Template Language
281647001 |Adverse reaction (disorder)|: [[~1..1]] { [[~0..1]] 363698007 |Finding site (attribute)| = [[+id(< 123037004 |Body structure (body structure)|) @site]], [[~1..1]] 246075003 |Causative agent (attribute)| = [[+id( << 105590001 |Substance (substance)| OR << 373873005 |Pharmaceutical / biologic product (product)| OR << 260787004 |Physical object (physical object)| OR << 78621006 |Physical force (physical force)|) @agent]] }
Applies to:
Scg expression |
---|
<< 282100009 |Adverse reaction caused by substance (disorder)| MINUS <<418634005 |Allergic reaction caused by substance (disorder)| |
Editorial guidelines for selection of Causative agent attribute value:
The following editorial guidelines apply to concepts in the International Release; editorial guidelines for concepts in national extensions may vary.
Causative agent |
---|
type | Allowed |
---|
Examples and Notes (Note: Examples are existing concepts and may not reflect the terming patterns described in the template.) | |
---|---|
Substance base |
yes | Adverse reaction concepts representing a substance base should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Example: |
|
|
Expected classification |
:
|
Substance |
modification | no |
Example:
, unless documented as exception | Adverse reaction concepts representing a substance modification should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Concepts representing substance modifications are exceptions and may be included if the adverse reaction profile is significantly different from the substance base. Exception examples:
Example: |
Expected classification |
:
|
|
|
| ||
Multiple substance | yes | Adverse reaction concepts representing multiple substances should be modeled |
using a Causative agent |
that is a descendant of 105590001 |Substance (substance)| |
; preferentially modeling with the base rather than a modification unless the adverse reaction profile is significantly different from the substance base. Example:
|
292389002 |Fluphenazine decanoate
|
|
|
|
Example:
292736001 |Opioid antagonist
Expected classification |
(Agreed 21-Jan-2020):
|
|
Disposition grouper |
Role groupers in the Substance hierarchy will be inactivated in a future release and should not be used for modeling in this subhierarchy. (Agreed 21-Jan-2020)
Insert examples of role grouper.
Example:
Expected classification results:
TBD if there are any restrictions on which product roles can be used in modeling in this subhierarchy
No use case has been identified for use of this concept type for modeling in this subhierarchy. Existing groupers representing role + structure will be inactivated and replaced with structure grouper. (Agreed 11-Feb-2020)
Example:
- 292320000 |Barbiturate antiepileptic adverse reaction (disorder)|
- 292337007 |Barbiturate sedative adverse reaction (disorder)|
- 292916005 |Benzimidazole anthelmintic adverse reaction (disorder)|
- 292343009 |Benzodiazepine sedative adverse reaction (disorder)|
yes | Adverse reaction concepts representing a disposition grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Example:
Expected classification results:
| |
Role grouper | yes | Adverse reaction concepts representing a role grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Note that role groupers will be transitioned to the 763158003 |Medicinal product (product)| hierarchy in a future release. Example:
Expected classification results (Agreed 21-Jan-2020):
|
Structure grouper | yes | Adverse reaction concepts representing a structure grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. |
Example:
Expected classification (Agreed 21-Jan-2020):
|
Body system groupers in both the Substance and Product hierarchies will be inactivated in a future release and should no longer be used for modeling in this hierarchy. (Agreed 21-Jan-2020)
Example:
293416008 |Drug groups primarily affecting cardiovascular systemDescendant of 373873005 |Pharmaceutical / biologic product (product)| | no, unless documented as exception | Exceptions: None identified |
The following types of groupers are out of scope; existing concepts have been inactivated or will be addressed in future release:
- Groupers based on more than one role (e.g. 292722006 |Chelating agents and antidotes adverse reaction (disorder)|
...
- )
- Groupers based on body system or intended site or route of administration (e.g. 292548001 |Drug groups primarily affecting
...
- respiratory system adverse reaction (disorder)|
...
Example:
- 292984002 |Ampicillin and cloxacillin adverse reaction (disorder)
- 292267003 |Benserazide + levodopa adverse reaction (disorder)
Expected classification results: Needs input from Drugs WG - see DRUGS-865
...
- ) or 417895009 |Topical agent adverse reaction (disorder)
...
- |
...
- )
...
- 292968003 |Ampicillin adverse reaction (disorder)| with Causative agent = 387170002 |Ampicillin (substance)|
- 292963007 |Cloxacillin adverse reaction (disorder)| with Causative agent = 373276005 |Cloxacillin (substance)|
- Groupers based on disposition, role, or structure combined with an individual substance (e.g. 287177000 |Sulfonamide/trimethoprim reaction (disorder)| or 292513008 |Methyldopa and diuretic adverse reaction (disorder)|)
- Groupers based on "combined" or "compound" substances (e.g. 292983008 |Combined penicillin preparation adverse reaction (disorder)| or 293358005 |Compound iron preparations adverse reaction (disorder)|)
- Groupers based on disposition or structure combined with intended site or route of administration (e.g. 433494006 |Adverse effect of oral diphosphonate (disorder)|)
- Groupers based on disposition combined with role (e.g. 292265006 |Dopaminergic drug used in parkinsonism adverse reaction (disorder)|)
...
- 292266007 |Levodopa adverse reaction (disorder)| with Causative agent = 387086006 |Levodopa (substance)|
- Note: There is not an existing concept for Adverse reaction to benserazide.
...
Example:
- 293543001 |Oral glyceryl trinitrate adverse reaction (disorder)
- 293545008 |Parenteral glyceryl trinitrate adverse reaction (disorder)
- 293546009 |Transdermal glyceryl trinitrate adverse reaction (disorder)
Expected classification results: Needs input from Drugs WG - see DRUGS-866
- 293543001 |Oral glyceryl trinitrate adverse reaction (disorder) will be modeled with Causative agent = 346460001 |Product containing glyceryl trinitrate in oral dose form (medicinal product form)| and will have the following inferred parents:
- 293542006 |Glyceryl trinitrate adverse reaction (disorder)| with Causative agent = 387404004 |Glyceryl trinitrate (substance)|
- 293542006 |Glyceryl trinitrate adverse reaction (disorder)| with Causative agent = 387404004 |Glyceryl trinitrate (substance)|
- 293545008 |Parenteral glyceryl trinitrate adverse reaction (disorder) will be modeled with Causative agent = 346461002 |Product containing glyceryl trinitrate in parenteral dose form (medicinal product form)| and will have the following inferred parents:
- 293542006 |Glyceryl trinitrate adverse reaction (disorder)| with Causative agent = 387404004 |Glyceryl trinitrate (substance)|
- 293542006 |Glyceryl trinitrate adverse reaction (disorder)| with Causative agent = 387404004 |Glyceryl trinitrate (substance)|
- 293546009 |Transdermal glyceryl trinitrate adverse reaction (disorder) will be modeled with Causative agent = 346462009 |Product containing glyceryl trinitrate in transdermal dose form (medicinal product form)|
- 293542006 |Glyceryl trinitrate adverse reaction (disorder)| with Causative agent = 387404004 |Glyceryl trinitrate (substance)|
...
No use case has been identified for use of this concept type for modeling in this subhierarchy.
...
Rules for description generation:
- For the FSN, align terming and case sensitivity with the FSN for the concept that is selected as the attribute value, excluding the semantic tag.
- For the PT, align terming and case sensitivity with the US and GB PT for the concept that is selected as the attribute value.
- In cases where neither the US or GB PT matches the FSN, excluding the semantic tag, a synonym corresponding to the FSN is required unless explicitly identified as an exception.
- Additional synonyms "[agent] adverse reaction" should be added. Other synonyms are not allowed unless explicitly identified as an exception.