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| Hierarchy | Concept type | Allowed | Exception | Examples and Notes - update examples to reflect final decision re: terming pattern |
|---|---|---|---|---|
| Substance | Base | yes | none | 292350008 |Alprazolam adverse reaction (disorder)| |
| Substance | Modification | no, unless explicitly documented as exception | TBD | TBD |
| Substance | Disposition grouper | yes | none | 292736001 |Opioid antagonist adverse reaction (disorder)| |
| Product | Disposition grouper | no | none | Note: Existing disposition groupers in the Product hierarchy should only exist as SD concepts with a corresponding concept in the Substance hierarchy. |
| Substance | Role grouper | no | none | Note: Existing role groupers in the Substance hierarchy will be inactivated and should no longer be used for modeling in this hierarchy. |
| Product | Role grouper | yes | none | TBD if there are any restrictions on which product roles can be used in modeling in this subhierarchy Grouper concepts should represent only a single role; groupers that represent multiple roles (e.g. hypnotic AND/OR sedative or Chelating agents and antidotes) are out of scope. |
| Substance | Structure grouper | yes | none | 218638005 |Adverse reaction caused by hydantoin derivative (disorder)| |
| Product | Structure grouper | no | none | Note: Existing disposition groupers in the Product hierarchy should only exist as SD concepts with a corresponding concept in the Substance hierarchy. |
| Product | Medicinal product-containing | TBD | TBD | TBD |
| Product | Medicinal product-only | TBD | TBD | TBD |
| Product | Medicinal product form-containing | TBD | TBD | TBD |
| Product | Medicinal product form-only | TBD | TBD | TBD |
| Product | Clinical drug | no | none | n/a |
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