Concept type | Allowed | Examples and Notes (Note: Examples are existing concepts and may not reflect the terming patterns described in the template.) |
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Substance base | yes | Adverse reaction concepts representing a substance base should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Example: - 292392003 |Fluphenazine adverse reaction (disorder)|
Expected classification (Agreed 21-Jan-2020): - Classification results are expected to be consistent with the modeling of the concept selected as the Causative agent in the Substance hierarchy. (Agreed 21-Jan-2019)
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Substance modification | yes, only if identified as accepted exception | Adverse reaction concepts representing a substance modification should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Concepts representing substance modifications are exceptions and may be included if the adverse reaction profile is significantly different from the substance base. Exception examples: - Chemical element with multiple modifications (e.g. 422232005 |Calcium lactate gluconate (substance)|)
- Liposome or lipid complex substances (e.g. 412088006 |Amphotericin B liposome (substance)|, 426490000 |Vincristine liposome (substance)|)
- Pegylated substance (e.g. 385544005 |Pegfilgrastim (substance)|, 770965008 |Pegvaliase (substance)|)
- Salt forms (e.g. 412432007 |Metoprolol succinate (substance)|, 72770009 |Metoprolol tartrate (substance)|)
Example: - 292389002 |Fluphenazine decanoate adverse reaction (disorder)|
- 292390006 |Fluphenazine enanthate adverse reaction (disorder)|
Expected classification (Agreed 21-Jan-2020): - Classification results are expected to be consistent with the modeling of the concept selected as the Causative agent in the Substance hierarchy. (Agreed 21-Jan-2019)
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Multiple substance | yes | Adverse reaction concepts representing multiple substances should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|; preferentially modeling with the base rather than a modification unless the adverse reaction profile is significantly different from the substance base. Example: - 292984002 |Ampicillin and cloxacillin adverse reaction (disorder)|
- 292987009 |Piperacillin and tazobactam adverse reaction (disorder)|
- 292989007 |Ticarcillin and clavulanic acid adverse reaction (disorder)|
Expected classification (Agreed 21-Jan-2020): - Classification results are expected to be consistent with the modeling of the concept selected as the Causative agent in the Substance hierarchy.
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Disposition grouper | yes | Adverse reaction concepts representing a disposition grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Example: - 293432006 |3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor adverse reaction (disorder)|
- 870376001 |Adverse reaction to dopamine receptor agonist (disorder)|
Expected classification results (Agreed 21-Jan-2020): - Classification results are expected to be consistent with the modeling in the Substance hierarchy for concepts modeled with an attribute value from the Substance hierarchy.
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Role grouper | no | Adverse reaction concepts representing a role grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Note that role groupers will be transitioned to the 763158003 |Medicinal product (product)| hierarchy in a future release. Example: - 430136001 |Adverse reaction caused by antiparkinsonism drug (disorder)|
- 292040004 |Analgesic adverse reaction (disorder)|
Expected classification results (Agreed 21-Jan-2020): - Classification results are expected to be consistent with the modeling in the Substance hierarchy for concepts modeled with an attribute value from the Substance hierarchy.
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Structure grouper | yes | Adverse reaction concepts representing a structure grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Example: - 218638005 |Adverse reaction caused by hydantoin derivative (disorder)|
- 419885006 |Beta lactam adverse reaction (disorder)|
Expected classification (Agreed 21-Jan-2020): - Classification results are expected to be consistent with the modeling in the Substance hierarchy and with other existing concepts in the subhierarchy.
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