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Adverse reaction concepts representing a substance base should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.

Example:

• 292392003 |Fluphenazine adverse reaction (disorder)|
  

Expected classification (Agreed 21-Jan-2020):

• Classification results are expected to be consistent with the modeling of the concept selected as the Causative agent in the Substance hierarchy. (Agreed 21-Jan-2019)

Adverse reaction concepts representing a substance modification should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Concepts representing substance modifications are exceptions and could be included if they meeting the following criteria.

Exceptions: NEED TO ADD CRITERIA

Example:

292389002 |Fluphenazine decanoate adverse reaction (disorder)|

Expected classification (Agreed 21-Jan-2020):

• Classification results are expected to be consistent with the modeling of the concept selected as the Causative agent in the Substance hierarchy. (Agreed 21-Jan-2019)

Adverse reaction concepts representing a disposition grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.

Example:

• 293432006 |3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor adverse reaction (disorder)|
• 870376001 |Adverse reaction to dopamine receptor agonist (disorder)|
  

Expected classification results (Agreed 21-Jan-2020):

• Classification results are expected to be consistent with the modeling in the Substance hierarchy for concepts modeled with an attribute value from the Substance hierarchy.

Adverse reaction concepts representing a role grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|. Note that role groupers will be transitioned to the 763158003 |Medicinal product (product)| hierarchy in future release.

Example:

• 430136001 |Adverse reaction caused by antiparkinsonism drug (disorder)|
• 292040004 |Analgesic adverse reaction (disorder)|

Expected classification results (Agreed 21-Jan-2020):

• Classification results are expected to be consistent with the modeling in the Substance hierarchy for concepts modeled with an attribute value from the Substance hierarchy.

No use case has been identified for use of this concept type for modeling in this subhierarchy. Existing groupers representing role + structure will be inactivated and replaced with structure grouper. (Agreed 11-Feb-2020)

Example:

• 292320000 |Barbiturate antiepileptic adverse reaction (disorder)|
• 292337007 |Barbiturate sedative adverse reaction (disorder)|
• 292916005 |Benzimidazole anthelmintic adverse reaction (disorder)|
• 292343009 |Benzodiazepine sedative adverse reaction (disorder)|

Adverse reaction concepts representing a structure grouper should be modeled using a Causative agent that is a descendant of 105590001 |Substance (substance)|.

Example:

• 218638005 |Adverse reaction caused by hydantoin derivative (disorder)|
  
• 419885006 |Beta lactam adverse reaction (disorder)|
  

Expected classification (Agreed 21-Jan-2020):

• Classification results are expected to be consistent with the modeling in the Substance hierarchy and with other existing concepts in the subhierarchy.

Body system groupers in both the Substance and Product hierarchies will be inactivated in a future release and should no longer be used for modeling in this hierarchy. (Agreed 21-Jan-2020)

Example:

• 293416008 |Drug groups primarily affecting cardiovascular system adverse reaction (disorder)|
• 292670005 |Drug groups primarily affecting musculoskeletal system adverse reaction (disorder)|

Example:

• 292984002 |Ampicillin and cloxacillin adverse reaction (disorder)
• 292267003 |Benserazide + levodopa adverse reaction (disorder)

Expected classification results: Needs input from Drugs WG - see DRUGS-865

• 292984002 |Ampicillin and cloxacillin adverse reaction (disorder) will be modeled with Causative agent = 346320003 |Product containing ampicillin and cloxacillin (medicinal product)| and will have the the following inferred parents:
  • 292968003 |Ampicillin adverse reaction (disorder)| with Causative agent = 387170002 |Ampicillin (substance)|
  • 292963007 |Cloxacillin adverse reaction (disorder)| with Causative agent = 373276005 |Cloxacillin (substance)|
• 292267003 |Benserazide + levodopa adverse reaction (disorder) will be modeled with Causative agent = 418467003 |Product containing benserazide and levodopa (medicinal product)| and will have the following inferred parents:
  • 292266007 |Levodopa adverse reaction (disorder)| with Causative agent = 387086006 |Levodopa (substance)|
    
  • Note: There is not an existing concept for Adverse reaction to benserazide.

Example:

• 293543001 |Oral glyceryl trinitrate adverse reaction (disorder)
• 293545008 |Parenteral glyceryl trinitrate adverse reaction (disorder)
• 293546009 |Transdermal glyceryl trinitrate adverse reaction (disorder)
  

Expected classification results: Needs input from Drugs WG - see DRUGS-866

• 293543001 |Oral glyceryl trinitrate adverse reaction (disorder) will be modeled with Causative agent = 346460001 |Product containing glyceryl trinitrate in oral dose form (medicinal product form)| and will have the following inferred parents:
  • 293542006 |Glyceryl trinitrate adverse reaction (disorder)| with Causative agent = 387404004 |Glyceryl trinitrate (substance)|
    
• 293545008 |Parenteral glyceryl trinitrate adverse reaction (disorder) will be modeled with Causative agent = 346461002 |Product containing glyceryl trinitrate in parenteral dose form (medicinal product form)| and will have the following inferred parents:
  • 293542006 |Glyceryl trinitrate adverse reaction (disorder)| with Causative agent = 387404004 |Glyceryl trinitrate (substance)|
    
• 293546009 |Transdermal glyceryl trinitrate adverse reaction (disorder) will be modeled with Causative agent = 346462009 |Product containing glyceryl trinitrate in transdermal dose form (medicinal product form)|
  
  • 293542006 |Glyceryl trinitrate adverse reaction (disorder)| with Causative agent = 387404004 |Glyceryl trinitrate (substance)|