Page History

Example:

• 292350008 |Adverse reaction to alprazolam (disorder)|

Expected classification (Agreed 21-Jan-2020):

• Classification results are expected to be consistent with the modeling in the Substance hierarchy. (Agreed 21-Jan-2019)

Example:

292392003 |Fluphenazine adverse reaction (disorder)|

292389002 |Fluphenazine decanoate adverse reaction (disorder)|

292390006 |Fluphenazine enanthate adverse reaction (disorder)|

Expected classification (Agreed 21-Jan-2020):

• Classification results are expected to be consistent with the modeling in the Substance hierarchy based on the Is modification attribute and with other existing concepts in the subhierarchy. Concepts modeled using a modification should have the concept modeled using the base as an inferred parent if such a concept exists.
• 292392003 |Fluphenazine adverse reaction (disorder)| will be modeled with Causative agent = 372730004 |Fluphenazine (substance)| and will have the following inferred descendants:
  
  • 292389002 |Fluphenazine decanoate adverse reaction (disorder)| with Causative agent = 396063006 |Fluphenazine decanoate (substance)|
    
  • 292390006 |Fluphenazine enanthate adverse reaction (disorder)| with Causative agent = 111125005 |Fluphenazine enanthate (substance)|
    

Example:

• 292736001 |Opioid antagonist adverse reaction (disorder)|

Expected classification results (Agreed 21-Jan-2020):

• Classification results are expected to be consistent with the modeling in the Substance hierarchy for concepts modeled with an attribute value from the Substance hierarchy.

Role groupers in the Substance hierarchy will be inactivated in a future release and should not be used for modeling in this subhierarchy. (Agreed 21-Jan-2020)

Insert examples of role grouper.

Example:

Expected classification results:

TBD if there are any restrictions on which product roles can be used in modeling in this subhierarchy

Example:

• 218638005 |Adverse reaction caused by hydantoin derivative (disorder)|
  

Expected classification (Agreed 21-Jan-2020):

• Classification results are expected to be consistent with the modeling in the Substance hierarchy and with other existing concepts in the subhierarchy.

Body system groupers in both the Substance and Product hierarchies will be inactivated in a future release and should no longer be used for modeling in this hierarchy. (Agreed 21-Jan-2020)

Example:

• 293416008 |Drug groups primarily affecting cardiovascular system adverse reaction (disorder)|
• 292670005 |Drug groups primarily affecting musculoskeletal system adverse reaction (disorder)|

Example:

• 292984002 |Ampicillin and cloxacillin adverse reaction (disorder)
• 292267003 |Benserazide + levodopa adverse reaction (disorder)

Expected classification results: NEEDS INTERNAL AGREEMENT - further discussion needed with Drug Project Group re: expectations for classification Needs input from Drugs WG - see DRUGS-865

• 292984002 |Ampicillin and cloxacillin adverse reaction (disorder) will be modeled with Causative agent = 346320003 |Product containing ampicillin and cloxacillin (medicinal product)| and will have the the following inferred parents:
  • 292968003 |Ampicillin adverse reaction (disorder)| with Causative agent = 387170002 |Ampicillin (substance)|
  • 292963007 |Cloxacillin adverse reaction (disorder)| with Causative agent = 373276005 |Cloxacillin (substance)|
• 292267003 |Benserazide + levodopa adverse reaction (disorder) will be modeled with Causative agent = 418467003 |Product containing benserazide and levodopa (medicinal product)| and will have the following inferred parents:
  • 292266007 |Levodopa adverse reaction (disorder)| with Causative agent = 387086006 |Levodopa (substance)|
    
  • Note: There is not an existing concept for Adverse reaction to benserazide.

Example:

• 293543001 |Oral glyceryl trinitrate adverse reaction (disorder)
• 293545008 |Parenteral glyceryl trinitrate adverse reaction (disorder)
• 293546009 |Transdermal glyceryl trinitrate adverse reaction (disorder)
  

Expected classification results: NEEDS INTERNAL AGREEMENT - further discussion needed with Drug Project Group re: expectations for classification Needs input from Drugs WG - see DRUGS-866

• 293543001 |Oral glyceryl trinitrate adverse reaction (disorder) will be modeled with Causative agent = 346460001 |Product containing glyceryl trinitrate in oral dose form (medicinal product form)| and will have the following inferred parents:
  • 293542006 |Glyceryl trinitrate adverse reaction (disorder)| with Causative agent = 387404004 |Glyceryl trinitrate (substance)|
    
• 293545008 |Parenteral glyceryl trinitrate adverse reaction (disorder) will be modeled with Causative agent = 346461002 |Product containing glyceryl trinitrate in parenteral dose form (medicinal product form)| and will have the following inferred parents:
  • 293542006 |Glyceryl trinitrate adverse reaction (disorder)| with Causative agent = 387404004 |Glyceryl trinitrate (substance)|
    
• 293546009 |Transdermal glyceryl trinitrate adverse reaction (disorder) will be modeled with Causative agent = 346462009 |Product containing glyceryl trinitrate in transdermal dose form (medicinal product form)|
  
  • 293542006 |Glyceryl trinitrate adverse reaction (disorder)| with Causative agent = 387404004 |Glyceryl trinitrate (substance)|

No use case has been identified for use of this concept type for modeling in this subhierarchy.

Extension model may provide sufficient use case for this.