Hierarchy | Concept type | Allowed | Exception | Examples and Notes - update examples to reflect final decision re: terming pattern |
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Substance | Base | yes | none | Example: - 292350008 |Alprazolam adverse reaction (disorder)|
Expected classification: NEEDS INTERNAL AGREEMENT - Classification results are expected to be consistent with the modeling in the Substance hierarchy and with other existing concepts in the subhierarchy.
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Substance | Modification | no | TBD | Example: 292392003 |Fluphenazine adverse reaction (disorder)| 292389002 |Fluphenazine decanoate adverse reaction (disorder)|
292390006 |Fluphenazine enanthate adverse reaction (disorder)| Expected classification: NEEDS INTERNAL AGREEMENT - Classification results are expected to be consistent with the modeling in the Substance hierarchy based on the Is modification attribute and with other existing concepts in the subhierarchy. Concepts modeled using a modification should have the concept modeled using the base as an inferred parent if such a concept exists.
- 292392003 |Fluphenazine adverse reaction (disorder)| will be modeled with Causative agent = 372730004 |Fluphenazine (substance)| and will have the following inferred descendants:
- 292389002 |Fluphenazine decanoate adverse reaction (disorder)| with Causative agent = 396063006 |Fluphenazine decanoate (substance)|
- 292390006 |Fluphenazine enanthate adverse reaction (disorder)| with Causative agent = 111125005 |Fluphenazine enanthate (substance)|
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Substance | Disposition grouper | yes | none | Example: - 292736001 |Opioid antagonist adverse reaction (disorder)|
Expected classification results:
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Product | Disposition grouper | no | none | No use case has been identified for use of this concept type for modeling in this subhierarchy. Disposition groupers in the Product hierarchy should only exist as SD concepts with a corresponding concept in the Substance hierarchy; the corresponding concept in the Substance hierarchy should be used for modeling in this subhierarchy.NEEDS INTERNAL AGREEMENT |
Substance | Role grouper | no | none | Role groupers in the Substance hierarchy will be inactivated in a future release and should not be used for modeling in this subhierarchy. NEEDS INTERNAL AGREEMENT |
Product | Role grouper | yes | none | Example: Expected classification results: TBD if there are any restrictions on which product roles can be used in modeling in this subhierarchy |
Substance | Structure grouper | yes | none | Example: - 218638005 |Adverse reaction caused by hydantoin derivative (disorder)|
Expected classification: NEEDS INTERNAL AGREEMENT - Classification results are expected to be consistent with the modeling in the Substance hierarchy and with other existing concepts in the subhierarchy.
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Product | Structure grouper | no | none | No use case has been identified for use of this concept type for modeling in this subhierarchy. Structure groupers in the Product hierarchy should only exist as SD concepts with a corresponding concept in the Substance hierarchy; the corresponding concept in the Substance hierarchy should be used for modeling in this subhierarchy. NEEDS INTERNAL AGREEMENT |
Product or Substance | Body system grouper | no | none | Body system groupers in both the Substance and Product hierarchies will be inactivated in a future release and should no longer be used for modeling in this hierarchy. NEEDS INTERNAL AGREEMENT Example: - 293416008 |Drug groups primarily affecting cardiovascular system adverse reaction (disorder)|
- 292670005 |Drug groups primarily affecting musculoskeletal system adverse reaction (disorder)|
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Product | Medicinal product-containing | yes | none | Example: - 292984002 |Ampicillin and cloxacillin adverse reaction (disorder)
- 292267003 |Benserazide + levodopa adverse reaction (disorder)
Expected classification results: NEEDS INTERNAL AGREEMENT - 292984002 |Ampicillin and cloxacillin adverse reaction (disorder) will be modeled with Causative agent = 346320003 |Product containing ampicillin and cloxacillin (medicinal product)| and will have the the following inferred parents:
- 292968003 |Ampicillin adverse reaction (disorder)| with Causative agent = 387170002 |Ampicillin (substance)|
- 292963007 |Cloxacillin adverse reaction (disorder)| with Causative agent = 373276005 |Cloxacillin (substance)|
- 292267003 |Benserazide + levodopa adverse reaction (disorder) will be modeled with Causative agent = 418467003 |Product containing benserazide and levodopa (medicinal product)| and will have the following inferred parents:
- 292266007 |Levodopa adverse reaction (disorder)| with Causative agent = 387086006 |Levodopa (substance)|
- Note: There is not an existing concept for Adverse reaction to benserazide.
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Product | Medicinal product-only | no | none | No use case has been identified for use of this concept type for modeling in this subhierarchy. Medicinal product-containing concepts can be used for modeling in this subhierarchy. NEEDS INTERNAL AGREEMENT |
Product | Medicinal product form-containing | yes | none | Example: - 293543001 |Oral glyceryl trinitrate adverse reaction (disorder)
- 293545008 |Parenteral glyceryl trinitrate adverse reaction (disorder)
- 293546009 |Transdermal glyceryl trinitrate adverse reaction (disorder)
Expected classification results: NEEDS INTERNAL AGREEMENT - 293543001 |Oral glyceryl trinitrate adverse reaction (disorder) will be modeled with Causative agent = 346460001 |Product containing glyceryl trinitrate in oral dose form (medicinal product form)| and will have the following inferred parents:
- 293542006 |Glyceryl trinitrate adverse reaction (disorder)| with Causative agent = 387404004 |Glyceryl trinitrate (substance)|
- 293545008 |Parenteral glyceryl trinitrate adverse reaction (disorder) will be modeled with Causative agent = 346461002 |Product containing glyceryl trinitrate in parenteral dose form (medicinal product form)| and will have the following inferred parents:
- 293542006 |Glyceryl trinitrate adverse reaction (disorder)| with Causative agent = 387404004 |Glyceryl trinitrate (substance)|
- 293546009 |Transdermal glyceryl trinitrate adverse reaction (disorder)
- 293542006 |Glyceryl trinitrate adverse reaction (disorder)| with Causative agent = 387404004 |Glyceryl trinitrate (substance)|
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Product | Medicinal product form-only | no | none | No use case has been identified for use of this concept type for modeling in this subhierarchy. Medicinal product form-containing concepts can be used for modeling in this subhierarchy. NEEDS INTERNAL AGREEMENT
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Product | Clinical drug | no | none | No use case has been identified for use of this concept type for modeling in this subhierarchy. NEEDS INTERNAL AGREEMENT |