Hierarchy | Concept type | Allowed | Exception | Examples and Notes - update examples to reflect final decision re: terming pattern |
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Substance | Base | yes | none | Example: - 292350008 |Alprazolam adverse reaction (disorder)|
Expected classification results: |
Substance | Modification | no | TBD | Example: Expected classification results: |
Substance | Disposition grouper | yes | none | Example: - 292736001 |Opioid antagonist adverse reaction (disorder)|
Expected classification results:
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Product | Disposition grouper | no | none | Disposition groupers in the Product hierarchy should only exist as SD concepts with a corresponding concept in the Substance hierarchy; the corresponding concept in the Substance hierarchy should be used for modeling in this subhierarchy. |
Substance | Role grouper | no | none | Role groupers in the Substance hierarchy will be inactivated in a future release and should not be used for modeling in this subhierarchy. |
Product | Role grouper | yes | none | Example: Expected classification results: TBD if there are any restrictions on which product roles can be used in modeling in this subhierarchy |
Substance | Structure grouper | yes | none | Example: - 218638005 |Adverse reaction caused by hydantoin derivative (disorder)|
Expected classification: |
Product | Structure grouper | no | none | Structure groupers in the Product hierarchy should only exist as SD concepts with a corresponding concept in the Substance hierarchy; the corresponding concept in the Substance hierarchy should be used for modeling in this subhierarchy. |
Product or Substance | Body system grouper | no | none | Body system groupers in both the Substance and Product hierarchies will be inactivated in a future release and should no longer be used for modeling in this hierarchy. Example: - 293416008 |Drug groups primarily affecting cardiovascular system adverse reaction (disorder)|
- 292670005 |Drug groups primarily affecting musculoskeletal system adverse reaction (disorder)|
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Product | Medicinal product-containing | yes | none | Example: - 292984002 |Ampicillin and cloxacillin adverse reaction (disorder)
- 292267003 |Benserazide + levodopa adverse reaction (disorder)
Expected classification results: NEEDS INTERNAL AGREEMENT - 292984002 |Ampicillin and cloxacillin adverse reaction (disorder) will be modeled with Causative agent = 346320003 |Product containing ampicillin and cloxacillin (medicinal product)| and will have the the following inferred parents:
- 292968003 |Ampicillin adverse reaction (disorder)| with Causative agent = 387170002 |Ampicillin (substance)|
- 292963007 |Cloxacillin adverse reaction (disorder)| with Causative agent = 373276005 |Cloxacillin (substance)|
- 292267003 |Benserazide + levodopa adverse reaction (disorder) will be modeled with Causative agent = 418467003 |Product containing benserazide and levodopa (medicinal product)| and will have the following inferred parents:
- 292266007 |Levodopa adverse reaction (disorder)| with Causative agent = 387086006 |Levodopa (substance)|
- Note: There is not an existing concept for Adverse reaction to benserazide.
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Product | Medicinal product-only | no | none | Medicinal product-containing concepts can be used for modeling in this subhierarchy. |
Product | Medicinal product form-containing | yes | none | Example: - 293543001 |Oral glyceryl trinitrate adverse reaction (disorder)
- 293545008 |Parenteral glyceryl trinitrate adverse reaction (disorder)
- 293546009 |Transdermal glyceryl trinitrate adverse reaction (disorder)
Expected classification results: NEEDS INTERNAL AGREEMENT - 293543001 |Oral glyceryl trinitrate adverse reaction (disorder) will be modeled with Causative agent = 346460001 |Product containing glyceryl trinitrate in oral dose form (medicinal product form)| and will have the following inferred parents:
- 293542006 |Glyceryl trinitrate adverse reaction (disorder)| with Causative agent = 387404004 |Glyceryl trinitrate (substance)|
- 293545008 |Parenteral glyceryl trinitrate adverse reaction (disorder) will be modeled with Causative agent = 346461002 |Product containing glyceryl trinitrate in parenteral dose form (medicinal product form)| and will have the following inferred parents:
- 293542006 |Glyceryl trinitrate adverse reaction (disorder)| with Causative agent = 387404004 |Glyceryl trinitrate (substance)|
- 293546009 |Transdermal glyceryl trinitrate adverse reaction (disorder)
- 293542006 |Glyceryl trinitrate adverse reaction (disorder)| with Causative agent = 387404004 |Glyceryl trinitrate (substance)|
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Product | Medicinal product form-only | no | none | Medicinal product form-containing concepts can be used for modeling in this subhierarchy.
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Product | Clinical drug | no | none | n/a |