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HierarchyConcept typeAllowedExceptionExamples and Notes - update examples to reflect final decision re: terming pattern
SubstanceBaseyesnone

Example:

  • 292350008 |Alprazolam adverse reaction (disorder)|

Expected classification results:

SubstanceModificationno, unless explicitly documented as exceptionTBD

Example:

Expected classification results:

SubstanceDisposition grouperyesnone

Example:

  • 292736001 |Opioid antagonist adverse reaction (disorder)|

Expected classification results:

ProductDisposition groupernononeDisposition groupers in the Product hierarchy should only exist as SD concepts with a corresponding concept in the Substance hierarchy; the corresponding concept in the Substance hierarchy should be used for modeling in this subhierarchy.
SubstanceRole groupernononeRole groupers in the Substance hierarchy will be inactivated in a future release and should not be used for modeling in this subhierarchy.
ProductRole grouperyesnone

Example:

Expected classification results:

TBD if there are any restrictions on which product roles can be used in modeling in this subhierarchy

SubstanceStructure grouperyesnone

Example:

  • 218638005 |Adverse reaction caused by hydantoin derivative (disorder)|

Expected classification:

ProductStructure groupernononeStructure groupers in the Product hierarchy should only exist as SD concepts with a corresponding concept in the Substance hierarchy; the corresponding concept in the Substance hierarchy should be used for modeling in this subhierarchy.
Product or SubstanceBody system groupernononeBody system groupers in both the Substance and Product hierarchies will be inactivated in a future release and should no longer be used for modeling in this hierarchy. ADD EXAMPLES
ProductMedicinal product-containingyesnone

Example:

  • 292984002 Ampicillin and cloxacillin adverse reaction (disorder)
  • 292267003 Benserazide + levodopa adverse reaction (disorder)

Expected classification results:

  • 292984002 Ampicillin and cloxacillin adverse reaction (disorder) will be modeled with Causative agent = 346320003 |Product containing ampicillin and cloxacillin (medicinal product)| and will have the the following inferred parents:
    • 292968003 |Ampicillin adverse reaction (disorder)| with Causative agent = 387170002 |Ampicillin (substance)|
    • 292963007 |Cloxacillin adverse reaction (disorder)| with Causative agent = 373276005 |Cloxacillin (substance)|
  • 292267003 Benserazide + levodopa adverse reaction (disorder) will be modeled with Causative agent = 418467003 |Product containing benserazide and levodopa (medicinal product)| and will have the following inferred parents:
    • 292266007 |Levodopa adverse reaction (disorder)| with Causative agent = 387086006 |Levodopa (substance)|
    • Note: There is not an existing concept for Adverse reaction to benserazide.
ProductMedicinal product-onlynononeNote: Medicinal product-containing can be used for modeling in the Adverse reaction caused by X subhierarchy.
ProductMedicinal product form-containingyesnone

Example:

Expected classification results:

ProductMedicinal product form-onlynononeNote: Medicinal product form-containing can be used for modeling in the Adverse reaction caused by X subhierarchy.
ProductClinical drugnononen/a

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