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HierarchyConcept typeAllowedExceptionExamples and Notes - update examples to reflect final decision re: terming pattern
SubstanceBaseyesnone

Example:

  • 292350008 |Alprazolam adverse reaction (disorder)|

Expected classification results:

SubstanceModificationno, unless explicitly documented as exceptionTBD

Example:

Expected classification results:

SubstanceDisposition grouperyesnone

Example:

  • 292736001 |Opioid antagonist adverse reaction (disorder)|

Expected classification results:

ProductDisposition groupernononeNote: Disposition groupers in the Product hierarchy should only exist as SD concepts with a corresponding concept in the Substance hierarchy; the corresponding concept in the Substance hierarchy should be used for modeling Adverse reaction to disposition grouper concepts.
SubstanceRole groupernononeNote: Role groupers in the Substance hierarchy will be inactivated in a future release and should no longer be used for modeling in this hierarchy.
ProductRole grouperyesnone

Example:

Expected classification results:

TBD if there are any restrictions on which product roles can be used in modeling in this subhierarchy

Grouper concepts should represent only a single role; groupers that represent multiple roles (e.g. hypnotic AND/OR sedative or Chelating agents and antidotes) are out of scope.

SubstanceStructure grouperyesnone

Example:

  • 218638005 |Adverse reaction caused by hydantoin derivative (disorder)|

Expected classification:

ProductStructure groupernononeNote: Structure groupers in the Product hierarchy should only exist as SD concepts with a corresponding concept in the Substance hierarchy; the corresponding concept in the Substance hierarchy should be used for modeling Adverse reaction to structure grouper concepts.
Product or SubstanceBody system groupernononeNote: Body system groupers in both the Substance and Product hierarchies will be inactivated in a future release and should no longer be used for modeling in this hierarchy. ADD EXAMPLES
ProductMedicinal product-containingyesnone

Example:

  • 292984002 Ampicillin and cloxacillin adverse reaction (disorder)
  • 292267003 Benserazide + levodopa adverse reaction (disorder)

Expected classification results:

  • 292984002 Ampicillin and cloxacillin adverse reaction (disorder) will have the following inferred parents:
    • 292968003 |Ampicillin adverse reaction (disorder)|
    • 292963007 |Cloxacillin adverse reaction (disorder)|
  • 292267003 Benserazide + levodopa adverse reaction (disorder) will have the following inferred parents:
    • 292266007 |Levodopa adverse reaction (disorder)|
    • Note: There is not an existing concept for Adverse reaction to benserazide.
ProductMedicinal product-onlynononeNote: Medicinal product-containing can be used for modeling in the Adverse reaction caused by X subhierarchy.
ProductMedicinal product form-containingyesnone

Example:

Expected classification results:

ProductMedicinal product form-onlynononeNote: Medicinal product form-containing can be used for modeling in the Adverse reaction caused by X subhierarchy.
ProductClinical drugnononen/a

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