B.2 Refinements - Invalid Expressions

Expression Constraint	INVALID Expression¹ ²
	Precoordinated	Postcoordinated
< 19829001 \|Disorder of lung\| : 116676008 \|Associated morphology\| = 79654002 \|Edema\|	19829001 \| Disorder of lung\|	19829001 \| Disorder of lung\| : 116676008 \| Associated morphology\| = 44132006 \| Abscess\|
	73452002 \| Abscess of lung\|
		19829001 \| Disorder of lung\| : 116676008 \| Associated morphology\| = 40829002 \| Acute edema\|
	233711002 \| Oxygen-induced pulmonary edema\|
< 19829001 \|Disorder of lung\| : 116676008 \|Associated morphology\| = << 79654002 \|Edema\|	19829001 \| Disorder of lung\|	6141006 \| Retinal edema\| : 116676008 \| Associated morphology\| = 103619005 \| Inflammatory edema\|
	73452002 \| Abscess of lung\|
		19829001 \| Disorder of lung\| : 116676008 \| Associated morphology\| = 44132006 \| Abscess\|
	6141006 \| Retinal edema\|
< 404684003 \|Clinical finding\| : 363698007 \|Finding site\| = << 39057004 \|Pulmonary valve structure\| , 116676008 \|Associated morphology\| = << 415582006 \|Stenosis\|	404684003 \| Clinical finding\|	448643005 \| Abnormality of pulmonary valve\| : 116676008 \| Associated morphology\| = 44132006 \| Abscess\|
	448643005 \| Abnormality of pulmonary valve\|
		404684003 \| Clinical finding\| : 363698007 \| Finding site\| = 61853006 \| Spinal canal structure\| , 116676008 \| Associated morphology\| = 415582006 \| Stenosis\|
	431238002 \| Abscess of pulmonary valve\|
* : 246075003 \|Causative agent\| = 387517004 \|Paracetamol\|	46093004 \| Paracetamol measurement\|	404684003 \| Clinical finding\| : 246075003 \| Causative agent\| = 372687004 \| Amoxicillin\|
< 404684003 \|Clinical finding\| : { 363698007 \|Finding site\| = << 39057004 \|Pulmonary valve structure\| , 116676008 \|Associated morphology\| = << 415582006 \|Stenosis\| }, { 363698007 \|Finding site\| = << 53085002 \|Right ventricular structure\| , 116676008 \|Associated morphology\| = << 56246009 \|Hypertrophy\| }	404684003 \| Clinical finding\|	404684003 \| Clinical finding\| : { 363698007 \| Finding site\| = 39057004 \| Pulmonary valve structure\| , 116676008 \| Associated morphology\| = 56246009 \| Hypertrophy\| }, { 363698007 \| Finding site\| = 53085002 \| Right ventricular structure\| , 116676008 \| Associated morphology\| = 415582006 \| Stenosis\| }
	56786000 \| Pulmonary valve stenosis\|
<< 404684003 \|Clinical finding\| : << 47429007 \|Associated with\| = << 267038008 \|Edema\|	404684003 \| Clinical finding\|	95356008 \| Mucosal ulcer\| : 42752001 \| Due to\| = 59901004 \| Cheek biting\|
< 27658006 \|Amoxicillin\| : 411116001 \|Has dose form\| = << 385055001 \|Tablet dose form\| , { 179999999100 \|Has basis of strength\| = ( 219999999102 \|Amoxicillin only\| : 189999999103 \|Has strength magnitude\| >= #200, 199999999101 \|Has strength unit\| = 258684004 \|mg\| )}	269999999100 \| Amoxicillin capsule\|	27658006 \| Amoxicillin\| : 411116001 \| Has dose form\| = 421026006 \| Oral tablet\| , { 179999999100 \| Has basis of strength\| = ( 219999999102 \| Amoxicillin only\| : 189999999103 \| Has strength magnitude\| = 175, 199999999101 \| Has strength unit\| = 258684004 \| mg\| )}
	374233002 \| Amoxicillin trihydrate 125 mg chewable tablet\|
< 27658006 \|Amoxicillin\| : 411116001 \|Has dose form\| = << 385055001 \|Tablet dose form\| , { 179999999100 \|Has basis of strength\| = ( 219999999102 \|Amoxicillin only\| : 189999999103 \|Has strength magnitude\| >= #500, 189999999103 \|Has strength magnitude\| <= #800, 199999999101 \|Has strength unit\| = 258684004 \|mg\| )}	269999999100 \| Amoxicillin capsule\|	27658006 \| Amoxicillin\| : 411116001 \| Has dose form\| = 421026006 \| Oral tablet\| , { 179999999100 \| Has basis of strength\| = ( 219999999102 \| Amoxicillin only\| : 189999999103 \| Has strength magnitude\| = #850, 199999999101 \| Has strength unit\| = 258684004 \| mg\| )}
	374647008 \| Amoxicillin 875 mg tablet\|
< 373873005 \|Pharmaceutical / biologic product\| : 209999999104 \|Has trade name\| = "PANADOL"	373873005 \| Pharmaceutical / biologic product\|	373873005 \| Pharmaceutical / biologic product\| : { 127489000 \| Has active ingredient\| = 412031009 \| Paracetamol or derivative\| , 209999999104 \| Has trade name\| = "PANADEINE"}
	322236009 \| Paracetamol 500mg tablet\|
< 91723000 \|Anatomical structure\| : R 363698007 \|Finding site\| = < 125605004 \|Fracture of bone\|	34080009 \| Malleus structure\|	34080009 \|Malleus structure\| : 272741003 \|Laterality\| = 7771000 \|Left\|
	10200004 \| Liver structure\|	10200004 \|Liver structure\| : 272741003 \|Laterality\| = 24028007 \|Right\|
< 125605004 \|Fracture of bone\| . 363698007 \|Finding site\|	34080009 \| Malleus structure\|	34080009 \|Malleus structure\| : 272741003 \|Laterality\| = 7771000 \|Left\|
	10200004 \| Liver structure\|	10200004 \|Liver structure\| : 272741003 \|Laterality\| = 24028007 \|Right\|
< 105590001 \|Substance\| : R << 127489000 \|Has active ingredient\| = < 27658006 \|Product containing amoxicillin\|	105590001 \| Substance\|	373873005 \| Pharmaceutical / biologic product\| : 127489000 \| Has active ingredient\| = 372687004 \| Amoxicillin\|
	387517004 \| Paracetamol\|
249999999101 \|TRIPHASIL tablet\| . 127489000 \|Has active ingredient\|	105590001 \| Substance\|	373873005 \| Pharmaceutical / biologic product\| : 127489000 \| Has active ingredient\| = 126109000 \| Levonorgestrel\|
	387517004 \| Paracetamol\|
< 404684003 \|Clinical finding\| : * = 79654002 \|Edema\|	263225007 \| Hip fracture\|	404684003 \| Clinical finding\| : 116676008 \| Associated morphology\| = 72704001 \| Fracture\|
	385933006 \| Edema control education\|
< 404684003 \|Clinical finding\| : 116676008 \|Associated morphology\| = *	195967001 \| Asthma\|	404684003 \| Clinical finding\| : 363698007 \| Finding site\| = 80891009 \| Heart structure\|
	73211009 \| Diabetes mellitus\|	404684003 \| Clinical finding\| : 246075003 \| Causative agent\| = 372687004 \| Amoxicillin\|

Footnotes
Ref	Notes
1	Please note that some of these examples are based on a hypothetical drug concept model.
2	The SNOMED CT identifiers created with the '9999999' namespace are for example only, and should not be used in a production environment.

Expression Constraint	INVALID Expression¹ ²
	Precoordinated	Postcoordinated
< 19829001 \|Disorder of lung\| : 116676008 \|Associated morphology\| = 79654002 \|Edema\|	19829001 \| Disorder of lung\|	19829001 \| Disorder of lung\| : 116676008 \| Associated morphology\| = 44132006 \| Abscess\|
	73452002 \| Abscess of lung\|
		19829001 \| Disorder of lung\| : 116676008 \| Associated morphology\| = 40829002 \| Acute edema\|
	233711002 \| Oxygen-induced pulmonary edema\|
< 19829001 \|Disorder of lung\| : 116676008 \|Associated morphology\| = << 79654002 \|Edema\|	19829001 \| Disorder of lung\|	6141006 \| Retinal edema\| : 116676008 \| Associated morphology\| = 103619005 \| Inflammatory edema\|
	73452002 \| Abscess of lung\|
		19829001 \| Disorder of lung\| : 116676008 \| Associated morphology\| = 44132006 \| Abscess\|
	6141006 \| Retinal edema\|
< 404684003 \|Clinical finding\| : 363698007 \|Finding site\| = << 39057004 \|Pulmonary valve structure\| , 116676008 \|Associated morphology\| = << 415582006 \|Stenosis\|	404684003 \| Clinical finding\|	448643005 \| Abnormality of pulmonary valve\| : 116676008 \| Associated morphology\| = 44132006 \| Abscess\|
	448643005 \| Abnormality of pulmonary valve\|
		404684003 \| Clinical finding\| : 363698007 \| Finding site\| = 61853006 \| Spinal canal structure\| , 116676008 \| Associated morphology\| = 415582006 \| Stenosis\|
	431238002 \| Abscess of pulmonary valve\|
* : 246075003 \|Causative agent\| = 387517004 \|Paracetamol\|	46093004 \| Paracetamol measurement\|	404684003 \| Clinical finding\| : 246075003 \| Causative agent\| = 372687004 \| Amoxicillin\|
< 404684003 \|Clinical finding\| : { 363698007 \|Finding site\| = << 39057004 \|Pulmonary valve structure\| , 116676008 \|Associated morphology\| = << 415582006 \|Stenosis\| }, { 363698007 \|Finding site\| = << 53085002 \|Right ventricular structure\| , 116676008 \|Associated morphology\| = << 56246009 \|Hypertrophy\| }	404684003 \| Clinical finding\|	404684003 \| Clinical finding\| : { 363698007 \| Finding site\| = 39057004 \| Pulmonary valve structure\| , 116676008 \| Associated morphology\| = 56246009 \| Hypertrophy\| }, { 363698007 \| Finding site\| = 53085002 \| Right ventricular structure\| , 116676008 \| Associated morphology\| = 415582006 \| Stenosis\| }
	56786000 \| Pulmonary valve stenosis\|
<< 404684003 \|Clinical finding\| : << 47429007 \|Associated with\| = << 267038008 \|Edema\|	404684003 \| Clinical finding\|	95356008 \| Mucosal ulcer\| : 42752001 \| Due to\| = 59901004 \| Cheek biting\|
< 27658006 \|Amoxicillin\| : 411116001 \|Has dose form\| = << 385055001 \|Tablet dose form\| , { 179999999100 \|Has basis of strength\| = ( 219999999102 \|Amoxicillin only\| : 189999999103 \|Has strength magnitude\| >= #200, 199999999101 \|Has strength unit\| = 258684004 \|mg\| )}	269999999100 \| Amoxicillin capsule\|	27658006 \| Amoxicillin\| : 411116001 \| Has dose form\| = 421026006 \| Oral tablet\| , { 179999999100 \| Has basis of strength\| = ( 219999999102 \| Amoxicillin only\| : 189999999103 \| Has strength magnitude\| = 175, 199999999101 \| Has strength unit\| = 258684004 \| mg\| )}
	374233002 \| Amoxicillin trihydrate 125 mg chewable tablet\|
< 27658006 \|Amoxicillin\| : 411116001 \|Has dose form\| = << 385055001 \|Tablet dose form\| , { 179999999100 \|Has basis of strength\| = ( 219999999102 \|Amoxicillin only\| : 189999999103 \|Has strength magnitude\| >= #500, 189999999103 \|Has strength magnitude\| <= #800, 199999999101 \|Has strength unit\| = 258684004 \|mg\| )}	269999999100 \| Amoxicillin capsule\|	27658006 \| Amoxicillin\| : 411116001 \| Has dose form\| = 421026006 \| Oral tablet\| , { 179999999100 \| Has basis of strength\| = ( 219999999102 \| Amoxicillin only\| : 189999999103 \| Has strength magnitude\| = #850, 199999999101 \| Has strength unit\| = 258684004 \| mg\| )}
	374647008 \| Amoxicillin 875 mg tablet\|
< 373873005 \|Pharmaceutical / biologic product\| : 209999999104 \|Has trade name\| = "PANADOL"	373873005 \| Pharmaceutical / biologic product\|	373873005 \| Pharmaceutical / biologic product\| : { 127489000 \| Has active ingredient\| = 412031009 \| Paracetamol or derivative\| , 209999999104 \| Has trade name\| = "PANADEINE"}
	322236009 \| Paracetamol 500mg tablet\|
< 91723000 \|Anatomical structure\| : R 363698007 \|Finding site\| = < 125605004 \|Fracture of bone\|	34080009 \| Malleus structure\|	34080009 \|Malleus structure\| : 272741003 \|Laterality\| = 7771000 \|Left\|
	10200004 \| Liver structure\|	10200004 \|Liver structure\| : 272741003 \|Laterality\| = 24028007 \|Right\|
< 125605004 \|Fracture of bone\| . 363698007 \|Finding site\|	34080009 \| Malleus structure\|	34080009 \|Malleus structure\| : 272741003 \|Laterality\| = 7771000 \|Left\|
	10200004 \| Liver structure\|	10200004 \|Liver structure\| : 272741003 \|Laterality\| = 24028007 \|Right\|
< 105590001 \|Substance\| : R << 127489000 \|Has active ingredient\| = < 27658006 \|Product containing amoxicillin\|	105590001 \| Substance\|	373873005 \| Pharmaceutical / biologic product\| : 127489000 \| Has active ingredient\| = 372687004 \| Amoxicillin\|
	387517004 \| Paracetamol\|
249999999101 \|TRIPHASIL tablet\| . 127489000 \|Has active ingredient\|	105590001 \| Substance\|	373873005 \| Pharmaceutical / biologic product\| : 127489000 \| Has active ingredient\| = 126109000 \| Levonorgestrel\|
	387517004 \| Paracetamol\|
< 404684003 \|Clinical finding\| : * = 79654002 \|Edema\|	263225007 \| Hip fracture\|	404684003 \| Clinical finding\| : 116676008 \| Associated morphology\| = 72704001 \| Fracture\|
	385933006 \| Edema control education\|
< 404684003 \|Clinical finding\| : 116676008 \|Associated morphology\| = *	195967001 \| Asthma\|	404684003 \| Clinical finding\| : 363698007 \| Finding site\| = 80891009 \| Heart structure\|
	73211009 \| Diabetes mellitus\|	404684003 \| Clinical finding\| : 246075003 \| Causative agent\| = 372687004 \| Amoxicillin\|

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B.2 Refinements - Invalid Expressions