September 12, 2019 minutes Allergy CRG meeting

Bruce Goldberg

Yongsheng Gao, Farzaneh Ashrafi, Bruce Goldberg

• Yongsheng Gao presented a proposal to link substances derived from organisms to organisms using property chaining and using this to model allergy to organisms which would then subsume allergy to substances derived from organisms
• Farzaneh Ashrafi presented work on creating substance grouper for various animal proteins

Recommendation to pursue Yongsheng Gao's approach

Yongsheng Gao's OWL sample ontology illustrating use of role chaining to link substance to organism: Allergy to animals.zip

• Bruce Goldberg to obtain a list of desired organisms from Natasha Krul and Marie-Alexandra Lambot

Bruce Goldberg, Marie-Alexandra Lambot

• Belgium cannot use SNOMED substances to document allergies and wishes to use Allergy to substance terms at this time.
• Marie-Alexandra Lambot has been working on creating lists of allergy to various substances based on the value set created by HL-7 that are absent from SNOMED CT

• Marie-Alexandra Lambot will add the missing allergy to substance concepts to her local extension and evaluate usage for eventual inclusion into the SNOMED core
• Bruce Goldberg to ask Cathy Richardson and Monica Harry about which countries may be using SNOMED allergy to substance concepts rather than just documenting allergies using substances and products

• Marie-Alexandra Lambot mentioned that many descendants of 411123000 |Diagnostic allergen extract (product)| and 104381000 |Allergen specific immunoglobulin E antibody measurement (procedure)| are not represented in SNOMED CT as corresponding allergy to substance concepts
  
  

Bruce Goldberg

• Cytotoxic and cytostatic often used interchangeably in clinical literature although can be differentiated based on studies in scientific literature
• Individual drugs may exhibit both properties possibly related to dose and other factors
• List of drugs that would be classified as cytotoxic vs. cytostatic is missing
• Requires use case
• Natasha Krul awaiting reply from her hospital pharmacologist to see if she knows of any medication that falls into one of the two categories. 
  • "The reason we came to this question was during our translation project. We saw synonyms in Snomed (cytotoxic and cytostatic) of which we werent sure if they were real synonyms and whether or not we should add them to our translations. I have asked several pharmacologists including a pharmacologist specialised in oncylytic medication and they all said that currently no distinction is made between cytotoxic and cytostatic. It depends on the dose whether a substance is toxic or static". 

• As the dose that would determine whether a substance is cytotoxic vs. cytostatic is unlikely to be standardized, this distinction will not be made in SNOMED CT

Bruce Goldberg, ALL

• Begin group review

• Task completed in SCA. Under review

• Tabled for a future meeting
  • https://authoring.ihtsdotools.org/#/tasks/task/INTQA/INTQA-2587/edit

Bruce Goldberg, All

• Next call Thursday October 10, 2019 20:00 UTC

• https://snomed.zoom.us/j/934143312

  Meeting ID: 934-143-312