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Date
Thursday, August 8, 2019
Schedule
2nd Thursday of every month
Time: 20:00 UTC
Objectives
- See discussion items below:
Discussion items
| Item | Description | Owner | Notes | Action |
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| 1 |
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| 2 | Allergy to animals | | - Allergy to furry animals (cats, dogs, etc.) represented in SNOMED CT as Allergy to animal x dander. Request from member of allergy CRG for more general allergy concept e.g. allergy to cat. An allergy is not caused by a living organism but rather a substance derived from that organism (usually a protein). Dander is one of several sources of allergenic proteins. In cats, exposure to the major cat allergen is in part due to a salivary allergen adhering to skin and hair during grooming. Some individuals may be allergic to proteins in cat urine.
- MedDRA also has concepts, Allergic to cats, Allergic to dogs, Allergic to horses, etc. so having something comparable would be helpful.
| Create general animal groupers with accompanying PT which reflects the accepted clinical idioms. - Ensure that the 'allergy substance (protein)' exists and include the animal insulin derived allergy substances within this hierarchy.
- CRG group members to propose detailed content required (see below*)
- Submit via CRS and prioritise appropriately and/or as part of Bruce Goldberg's work in the allergy group.
*We (Natasha Krul )have a very active allergist in an academic hospital who has provided us with a list of relevant allergens. He has divided the list into categories like inhalation allergens, food allergens etc. and for each group of allergens he would like a 'header' for instance 'pulse vegetables' as a header for peas, peanuts, beans etc so the allergist who is registering the information can choose what level he wants to register in. I understand there a plans to create a 'header' in Snomed for animal feathers, protein, dander, epithelium? Am I correct? |
| 3 | Allergen and Allergy to substance refset for Belgium | | | |
| 4 | Cytostatic vs. cytotoxic drugs | | - There is a 372688009|Antineoplastic agent (substance)| in Snomed with a child 373526007|Cytotoxic (substance)|. We were wondering why Snomed doesn't have a separate concept for Cytostatic (substance)?
- We have seen that Snomed sees antineoplastic agent synonomous to cytostatic agent for instance in 292196008|Antineoplastic adverse reaction| which is defined with antineoplastic agent as a causative agent.
- An antineoplastic agent can be cytotoxic (killing the cells) or cytostatic (inhibiting growth but not killing them) Is there a reason or explanation why the Snomed hierarchy does not contain a cytostatic (substance)?
| - Cytotoxic and cytostatic often used interchangeably in clinical literature although can be differentiated based on studies in scientific literature
- Individual drugs may exhibit both properties possibly related to dose and other factors
- List of drugs that would be classified as cytotoxic vs. cytostatic is missing
- Requires use case
- Natasha Krul awaiting reply from her hospital pharmacologist to see if she knows of any medication that falls into one of the two categories.
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| 2 | Allergy to substance remediation project | | |
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| 4 | Allergy to alpha-gal and alpha-gal syndrome | Bruce Goldberg | - Task completed in SCA. Under review
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| 6 | Adjourn | | | |
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