A.2 Refinements

Expression Constraint	Valid Expression¹ ²
Expression Constraint	Precoordinated	Postcoordinated
< 19829001 \|Disorder of lung\| : 116676008 \|Associated morphology\| = 79654002 \|Edema\|	11468004 \|Postoperative pulmonary edema\|	210051003 \|Injury to heart and lung\| : 116676008 \|Associated morphology\| = 79654002 \|Edema\|
	276637009 \|Hemorrhagic pulmonary edema\|
< 19829001 \|Disorder of lung\| : 116676008 \|Associated morphology\| = << 79654002 \|Edema\|	233709006 \|Toxic pulmonary edema\|	275504005 \|Lung cyst\| : 116676008 \|Associated morphology\| = 103619005 \|Inflammatory edema\|
	233711002 \|Oxygen-induced pulmonary edema\|	19829001 \|Disorder of lung\| : 116676008 \|Associated morphology\| = 40829002 \|Acute edema\|
< 404684003 \|Clinical finding\| : 363698007 \|Finding site\| = << 39057004 \|Pulmonary valve structure\| , 116676008 \|Associated morphology\| = << 415582006 \|Stenosis\|	56786000 \|Pulmonic valve stenosis\|	56786000 \|Pulmonic valve stenosis\| : 363698007 \|Finding site\| = 90318009 \|Structure of anulus fibrosus of pulmonary artery\| , 116676008 \|Associated morphology\| = 88015002 \|Partial stenosis\|
	86299006 \|Tetralogy of Fallot\|	404684003 \|Clinical finding\| : 363698007 \|Finding site\| = 39057004 \|Pulmonary valve structure\| , 116676008 \|Associated morphology\| = 415582006 \|Stenosis\|
* : 246075003 \|Causative agent\| = 387517004 \|Paracetamol\|	295124009 \|Paracetamol overdose\|	404684003 \|Clinical finding\| : 246075003 \|Causative agent\| = 387517004 \|Paracetamol\|
* : 246075003 \|Causative agent\| = 387517004 \|Paracetamol\|	292042007 \|Adverse reaction to paracetamol\|
< 404684003 \|Clinical finding\| : { 363698007 \|Finding site\| = << 39057004 \|Pulmonary valve structure\| , 116676008 \|Associated morphology\| = << 415582006 \|Stenosis\| }, { 363698007 \|Finding site\| = << 53085002 \|Right ventricular structure\| , 116676008 \|Associated morphology\| = << 56246009 \|Hypertrophy\| }	86299006 \|Tetralogy of Fallot\|	404684003 \|Clinical finding\| : { 363698007 \|Finding site\| = 31689007 \|Structure of cusp of pulmonic valve\| , 116676008 \|Associated morphology\| = 415582006 \|Stenosis\| }, { 363698007 \|Finding site\| = 53085002 \|Right ventricular structure\| , 116676008 \|Associated morphology\| = 125521000 \|Acute hypertrophy\| }
	204351007 \|Fallot's trilogy\|
< 404684003 \|Clinical finding\| : 47429007 \|Associated with\| = (< 404684003 \|Clinical finding\| : 116676008 \|Associated morphology\| = << 55641003 \|Infarct\| )	71023004 \|Pericarditis secondary to acute myocardial infarction\|	64572001 \|Disease\| : 47429007 \|Associated with\| = ( 404684003 \|clinical finding\| : 116676008 \|associated morphology\| = 55641003 \|infarct\| , 363698007 \|finding site\| = 277712000 \|cardiac internal structure\| )
<< 404684003 \|Clinical finding\| : << 47429007 \|Associated with\| = << 267038008 \|Edema\|	230580009 \|Myxedema neuropathy\|	95356008 \|Mucosal ulcer\| : 42752001 \|Due to\| = 40829002 \|Acute edema\|
< 111115 111115 \|Amoxicillin tablet\| : { 127489000 \|Has active ingredient\| = 372687004 \|Amoxicillin\| , 111115 111115 \|Has reference basis of strength\| = 372687004 \|Amoxicillin\| , 111115 111115 \|Strength magnitude equal to\| >= #500, 111115 500111115 \|Strength unit\| = 258684004 \|mg\| }	111115 111115 \|Amoxicillin trihydrate 500 mg tablet\|	111115 111115 \|Amoxicillin tablet\| : 111115 111115 \|Has dose form\| = 421026006 \|Oral tablet\| , { 127489000 \|Has active ingredient\| = 372687004 \|Amoxicillin\| , 111115 111115 \|Has reference basis of strength\| = 372687004 \|Amoxicillin\| , 111115 111115 \|Strength magnitude equal to\| = #500, 111115 500111115 \|Strength unit\| = 258684004 \|mg\| }
< 111115 111115 \|Amoxicillin tablet\| : { 127489000 \|Has active ingredient\| = 372687004 \|Amoxicillin\| , 111115 111115 \|Has reference basis of strength\| = 372687004 \|Amoxicillin\| , 111115 111115 \|Strength magnitude equal to\| >= #500, 111115 500111115 \|Strength magnitude equal to\| <= #800, 111115 800111115 \|Strength unit\| = 258684004 \|mg\| }	111115 111115 \|Amoxicillin trihydrate 750 mg tablet\|	111115 111115 \|Amoxicillin tablet\| : { 127489000 \|Has active ingredient\| = 372687004 \|Amoxicillin\| , 111115 111115 \|Has reference basis of strength\| = 372687004 \|Amoxicillin\| , 111115 111115 \|Strength magnitude equal to\| = #600, 111115 600111115 \|Strength unit\| = 258684004 \|mg\| }
< 373873005 \|Pharmaceutical / biologic product\| : 111115 111115 \|Trade name\| = "PANADOL"	111115 111115 \|PANADOL [paracetamol] tablet\|	373873005 \|Pharmaceutical / biologic product\| : { 127489000 \|Has active ingredient\| = 412031009 \|Paracetamol or derivative\| }, 111115 111115 \|Trade name\| = "PANADOL"
< 105590001 \|Substance\| : R 127489000 \|Has active ingredient\| = 111115 111115 \|TRIPHASIL tablet\|	126109000 \|Levonorgestrel\|	-
	126097006 \|Ethinylestradiol\|	-
< 404684003 \|Clinical finding\| : * = 79654002 \|Edema\|	19242006 \|Pulmonary edema\|	404684003 \|Clinical finding\| : 116676008 \|Associated morphology\| = 79654002 \|Edema\|
< 404684003 \|Clinical finding\| : * = 79654002 \|Edema\|	97341000119105 \|Proliferative retinopathy with retinal edema due to type 2 diabetes mellitus\|
< 404684003 \|Clinical finding\| : 116676008 \|Associated morphology\| = *	19242006 \|Pulmonary edema\|	404684003 \|Clinical finding\| : 116676008 \|Associated morphology\| = 79654002 \|Edema\|
	263225007 \|Hip fracture\|	404684003 \|Clinical finding\| : 116676008 \|Associated morphology\| = 72704001 \|Fracture\|

Footnotes
Ref	Notes
1	Please note that these examples are based on a hypothetical drug concept model.
2	Concepts for which an identifier has not yet been assigned have been shown with an identifier of ‘111115’.

Expression Constraint	Valid Expression¹ ²
Expression Constraint	Precoordinated	Postcoordinated
< 19829001 \|Disorder of lung\| : 116676008 \|Associated morphology\| = 79654002 \|Edema\|	11468004 \|Postoperative pulmonary edema\|	210051003 \|Injury to heart and lung\| : 116676008 \|Associated morphology\| = 79654002 \|Edema\|
	276637009 \|Hemorrhagic pulmonary edema\|
< 19829001 \|Disorder of lung\| : 116676008 \|Associated morphology\| = << 79654002 \|Edema\|	233709006 \|Toxic pulmonary edema\|	275504005 \|Lung cyst\| : 116676008 \|Associated morphology\| = 103619005 \|Inflammatory edema\|
	233711002 \|Oxygen-induced pulmonary edema\|	19829001 \|Disorder of lung\| : 116676008 \|Associated morphology\| = 40829002 \|Acute edema\|
< 404684003 \|Clinical finding\| : 363698007 \|Finding site\| = << 39057004 \|Pulmonary valve structure\| , 116676008 \|Associated morphology\| = << 415582006 \|Stenosis\|	56786000 \|Pulmonic valve stenosis\|	56786000 \|Pulmonic valve stenosis\| : 363698007 \|Finding site\| = 90318009 \|Structure of anulus fibrosus of pulmonary artery\| , 116676008 \|Associated morphology\| = 88015002 \|Partial stenosis\|
	86299006 \|Tetralogy of Fallot\|	404684003 \|Clinical finding\| : 363698007 \|Finding site\| = 39057004 \|Pulmonary valve structure\| , 116676008 \|Associated morphology\| = 415582006 \|Stenosis\|
* : 246075003 \|Causative agent\| = 387517004 \|Paracetamol\|	295124009 \|Paracetamol overdose\|	404684003 \|Clinical finding\| : 246075003 \|Causative agent\| = 387517004 \|Paracetamol\|
* : 246075003 \|Causative agent\| = 387517004 \|Paracetamol\|	292042007 \|Adverse reaction to paracetamol\|
< 404684003 \|Clinical finding\| : { 363698007 \|Finding site\| = << 39057004 \|Pulmonary valve structure\| , 116676008 \|Associated morphology\| = << 415582006 \|Stenosis\| }, { 363698007 \|Finding site\| = << 53085002 \|Right ventricular structure\| , 116676008 \|Associated morphology\| = << 56246009 \|Hypertrophy\| }	86299006 \|Tetralogy of Fallot\|	404684003 \|Clinical finding\| : { 363698007 \|Finding site\| = 31689007 \|Structure of cusp of pulmonic valve\| , 116676008 \|Associated morphology\| = 415582006 \|Stenosis\| }, { 363698007 \|Finding site\| = 53085002 \|Right ventricular structure\| , 116676008 \|Associated morphology\| = 125521000 \|Acute hypertrophy\| }
	204351007 \|Fallot's trilogy\|
< 404684003 \|Clinical finding\| : 47429007 \|Associated with\| = (< 404684003 \|Clinical finding\| : 116676008 \|Associated morphology\| = << 55641003 \|Infarct\| )	71023004 \|Pericarditis secondary to acute myocardial infarction\|	64572001 \|Disease\| : 47429007 \|Associated with\| = ( 404684003 \|clinical finding\| : 116676008 \|associated morphology\| = 55641003 \|infarct\| , 363698007 \|finding site\| = 277712000 \|cardiac internal structure\| )
<< 404684003 \|Clinical finding\| : << 47429007 \|Associated with\| = << 267038008 \|Edema\|	230580009 \|Myxedema neuropathy\|	95356008 \|Mucosal ulcer\| : 42752001 \|Due to\| = 40829002 \|Acute edema\|
< 111115 111115 \|Amoxicillin tablet\| : { 127489000 \|Has active ingredient\| = 372687004 \|Amoxicillin\| , 111115 111115 \|Has reference basis of strength\| = 372687004 \|Amoxicillin\| , 111115 111115 \|Strength magnitude equal to\| >= #500, 111115 500111115 \|Strength unit\| = 258684004 \|mg\| }	111115 111115 \|Amoxicillin trihydrate 500 mg tablet\|	111115 111115 \|Amoxicillin tablet\| : 111115 111115 \|Has dose form\| = 421026006 \|Oral tablet\| , { 127489000 \|Has active ingredient\| = 372687004 \|Amoxicillin\| , 111115 111115 \|Has reference basis of strength\| = 372687004 \|Amoxicillin\| , 111115 111115 \|Strength magnitude equal to\| = #500, 111115 500111115 \|Strength unit\| = 258684004 \|mg\| }
< 111115 111115 \|Amoxicillin tablet\| : { 127489000 \|Has active ingredient\| = 372687004 \|Amoxicillin\| , 111115 111115 \|Has reference basis of strength\| = 372687004 \|Amoxicillin\| , 111115 111115 \|Strength magnitude equal to\| >= #500, 111115 500111115 \|Strength magnitude equal to\| <= #800, 111115 800111115 \|Strength unit\| = 258684004 \|mg\| }	111115 111115 \|Amoxicillin trihydrate 750 mg tablet\|	111115 111115 \|Amoxicillin tablet\| : { 127489000 \|Has active ingredient\| = 372687004 \|Amoxicillin\| , 111115 111115 \|Has reference basis of strength\| = 372687004 \|Amoxicillin\| , 111115 111115 \|Strength magnitude equal to\| = #600, 111115 600111115 \|Strength unit\| = 258684004 \|mg\| }
< 373873005 \|Pharmaceutical / biologic product\| : 111115 111115 \|Trade name\| = "PANADOL"	111115 111115 \|PANADOL [paracetamol] tablet\|	373873005 \|Pharmaceutical / biologic product\| : { 127489000 \|Has active ingredient\| = 412031009 \|Paracetamol or derivative\| }, 111115 111115 \|Trade name\| = "PANADOL"
< 105590001 \|Substance\| : R 127489000 \|Has active ingredient\| = 111115 111115 \|TRIPHASIL tablet\|	126109000 \|Levonorgestrel\|	-
	126097006 \|Ethinylestradiol\|	-
< 404684003 \|Clinical finding\| : * = 79654002 \|Edema\|	19242006 \|Pulmonary edema\|	404684003 \|Clinical finding\| : 116676008 \|Associated morphology\| = 79654002 \|Edema\|
< 404684003 \|Clinical finding\| : * = 79654002 \|Edema\|	97341000119105 \|Proliferative retinopathy with retinal edema due to type 2 diabetes mellitus\|
< 404684003 \|Clinical finding\| : 116676008 \|Associated morphology\| = *	19242006 \|Pulmonary edema\|	404684003 \|Clinical finding\| : 116676008 \|Associated morphology\| = 79654002 \|Edema\|
	263225007 \|Hip fracture\|	404684003 \|Clinical finding\| : 116676008 \|Associated morphology\| = 72704001 \|Fracture\|

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A.2 Refinements