General issues
Primitive concepts
Can we investigate ways to make currently primitive dose forms fully defined?
For example, for nebulizer solutions… is there the potential to add the administration device from the physical object hierarchy?
Irrigation as a new method of administration
"the process of washing out an organ or wound with a continuous flow of water or medication" - the concept is the "continuous flow" rather than the "apply" or the "bathe"
Specific issues
385213000: Conventional release vapor solution for inhalation (dose form)
We feel this should not be “no transformation” BUT we also freel the EDQM transform of “mixing” doesn’t feel right. The AdmDF would be “vapour for inhalation”. But “mixing” is not the correct transformation as can put solution on a handkerchief and inhale the vapour directly
| Dose form | Comments |
|---|---|
| Prolonged-release solution for injection | Used for products like Buvidal, where it is the dose form (the formulation of the solution for injection)at causes the prolonged release; the substance is (still) plain buprenorphine |
| Oral/rectal solution (and others) | Multiple intended site dose forms should be included, following the pattern that already exists for eye/ear/nose drops. BUT not all EDQM should be added - there should be evaluation (e.g. EDQM have rejected a "Solution for injection/infusion/rectal use" concept because "it is not appropriate for safety reasons, owing to the different microbiological requirements for the routes of administration covered" For the decision support use case, grouping concepts by their intended site is often very helpful (for example) |