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1. Focus on synoptic reporting uses.
2. Examples:
   1. Breast cancer her2 from breast tissue (typical scenario)
   2. breast cancer her2 from lymph node (metastatic scenario)

Note: This defers metastatic observable to the info model

b. her2 in breast cancer from lymph node

Continue discussion:

What are we measuring when assessing "treatment effect"?  

Is this a histologic change?  Viability of tumor cells?

1. Primary site
2. Lymph node

Note: SSA wonders about property in this model

Will review model.  This observable pertains to the process of regression/change in the neoplasm after antineoplastic therapy.  So, observable could be modeled as presence of process changes.