Page History

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Creation of substance concepts that contain terms such as “free” (or "unbound" or "unconjugated") is limited to the measurement of biological substances (Observable entities, evaluation procedures, LOINC collaboration project) or to report their level (clinical findings). These concepts are created as siblings of the base concepts with a "substance X and X derivatives" or "X and X compound" as common supertype.

Modeling

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Parent concept	Most distal appropriate descendant of 105590001 |Substance (substance)|

Exceptions: none

Semantic tag	(substance)
Definition status

900000000000074008 |Necessary but not sufficient concept definition status (core metadata concept)|

• Exceptions: none

Primitive
Attribute	726542003 |Has disposition (attribute)|

Naming

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FSN	Pattern:

Free X (substance)

Example:

For example, Free iodine (substance)
Preferred Term	Pattern:

Free X

Example:

For example, Free iodine
Synonyms

PatternOptional:

Optional pattern:

Unbound x For example,

Unbound iodine

Example:

Exemplar

The following illustrates both the stated and inferred view:

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