Conflicts of interest

Notice of recording

• Issues from the vital signs modelling

Discuss this paper in light of the new drug model. Specifically how the new model resolves many of the issues with incorrect inferences related to the IS A hierarchy in substances.

Smashing the strict hierarchy

• Batch editing of the disorder/findings hierarchy to transform it into a representation with a "naked kernel" clinical entities hierarchy (no soft defaults)
• Additional auxiliary hierarchies supporting better modeling patterns
• An observation/statement/assertion/phenomena hierarchy that would explicitly represent context (e.g. presence/absence) while supporting correct aggregation of some absence patterns. 

Revisit the intended meaning and operational consequences of the nine subflavours of 900000000000522004|Historical association reference set (foundation metadata concept)|

• ‘historical associations’ are to be declared between inactive concepts and their candidate active (and so taxonomically reportable) substitute(s).
• Sections within the RefSets Practical and Terminology Services guide mention that such associations exist - though they’re rather silent on what you can or should do with them.
• No obviously visible guidance (e.g. in the new Editorial Guide) on how and why authors should decide what makes a ‘good association’
• Not a lot of understanding of the possible consequences of a bad or missing one.