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1. A subset of components. 
   • Two patients are included in a query which analyzes encoded health records and checks for membership in the appropriate subset. E.g. patients with a finding included in the rare diseases reference set.
2. A subset of components and subsumption testing.   
   • Three  patients are included in a query which test the codes recorded in patient records and check for membership in the appropriate subset or descendants of the subset members. E.g. patients with an associated finding that is referenced in the rare diseases reference set, or any subtypes of the concepts in the reference set.