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This attribute is used to represent both the course and onset of of a disease or condition.      This attribute is self-grouped.  

For example, 

    • Concept
      t74973004 |Chronic fibrosing pancreatitis (disorder)|
       has a 
      Concept
      t263502005 |Clinical course (attribute)|
       of 
      Concept
      t90734009 |Chronic (qualifier value)|

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Note
titleThe word acute

The word acute has more than one meaning, and the meanings are often overlapping or unclear. It may imply rapid onset, short duration, or high severity; in some circumstances it might be used to mean all of these. For morphological concepts, acute may also imply the kind of morphology associated with the speed of onset.

For example,

    • Concept
      t4532008 |Acute inflammation (morphologic abnormality)|
      does not necessarily have a clinical course of sudden onset and/or short duration, but rather implies polymorphonuclear infiltration (
      Concept
      t84499006 |Chronic inflammation (morphologic abnormality)|
       implies mononuclear cell infiltration, not necessarily a chronic course, although inflammation with a chronic course is highly correlated with a lymphocytic infiltration)

2704003 |Acute disease (disorder)| is modeled with a Clinical course (attribute) of Sudden onset AND/OR short duration (qualifier value).  For clinical conditions that necessitate further specificity, the more appropriate subtypes are available.  Acute onset and sudden onset are synonymous; clinical conditions specifying acute onset should be modeled with a Clinical course (attribute) of Sudden onset (qualifier value).

Normally, 

Concept
t263502005 |Clinical course (attribute)|
 is self-grouped, meaning not grouped with other attributes.  However, an exception to this rule was made for Alpha gal syndrome.  Because the clinical course describes the realization and not the entire concept itself, the Clinical course (attribute) is grouped with the 719722006 |Has realization (attribute)|.   

Concept
t788781001 |Delayed allergy to red meat (finding)|

...

Concept
t263502005 |Clinical course (attribute)|

...

Concept
t788800008 |Delayed onset (qualifier value)|

...

Concept
t719722006 |Has realization (attribute)|

...

Concept
t769260004 |Immunoglobulin E-mediated allergic process (qualifier value)|

...

Concept
t226915003 |Red meat (substance)|

...

Concept
t788778006 |Galactose-alpha-1,3 galactose (substance)|

...

Concept
t788779003 |Allergy to galactose-alpha-1,3 galactose (finding)|

...

Concept
t788781001 |Delayed allergy to red meat (finding)|

.

Due to

This attribute is used to identify a clinical finding/disorder, event, or procedure concept as the direct cause of another Clinical finding or Disorder concept.  If the clinical finding merely predisposes to another disorder, rather than causing it directly, the more general

Concept
tAssociated with (attribute)
 is used instead.  

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