Page History

...

Modeling using the IS Modification attribute (stated view)

Exemplar

The following illustrates the stated view

...

For example, Doxepin hydrochloride (substance)

Hydrates have Hydrates have a IS MODIFICATION OF relationship to the unspecified salt.

For example, Caffeine hydrate (substance)  IS IS MODIFICATION of OF Caffeine (substance)

This is the stated view.

...

For example, Clindamycin hydrochloride monohydrate (substance) IS IS MODIFICATION of OF Clindamycin hydrochloride hydrochloride (substance)

        This is the stated view:

...

For example, Calcium lactate pentahydrate (substance)  IS IS MODIFICATION of OF Calcium lactate (substance)

...

For example, Theophylline anhydrous (substance)  IS IS MODIFICATION of Theophylline OF Theophylline (substance)

This is the stated view

...

The salts are modeled with an IS Modification to OF the acid substance.

For example, Pamidronate monosodium (substance) IS MODIFICATION of OF Pamidronic acid (substance).  This This is the stated and inferred view.

...

Pegylated substances should be modelled as "Is_modification" of modeled with |Is modification of (attribute)| generic substance–if such a substance has been made available; not all pegylated medicinal substances have a non-pegylated form as the non-pegylated form may have been too immunogenic or too toxic.

...

Grouper concepts should not be targets of an "Is_modification” relationship.

In general, “Is modification” relationship an |Is modification of (attribute)| is not applicable to prodrugs. For example, aspirin is not generally considered as a modification of the substance salicylic acid. This is because there is no requirement for the “has |Has active ingredient” ingredient (attribute)| of medicinal products containing prodrug substances to use any relationship to the active substance to manage relationships within the medicinal product hierarchy. 

...