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# | ConceptId | Term | Status | Action / Plan | Discussion |
|---|---|---|---|---|---|
| 1 | 840651000 | Conventional release chewable capsule (dose form) | Not Referenced | See https://request.ihtsdotools.org/#/requests/preview/766062?fromList=true request from François Macary Hi François, The existing Pharmaceutical dose form concept and the associated Clinical drug concept modeled using it have been inactivated and replaced because the requested changes for the Basic dose form would alter the meaning of the concepts. The addition of an additional Administration method will be addressed at a later date; it is a change that needs to be done systematically for all affected concepts and also requires additional testing and perhaps a concept model change. Kind regards, | |
| 2 | 421873001 | Conventional release oral cream (dose form) | Not Referenced | Looking in browser the inactivation target is 1217290000 |Conventional release oromucosal cream (dose form)|. Can see this was added based on a request from François Macary referencing EDQM PDF mapping; e-prescribe; e-dispense: https://request.ihtsdotools.org/#/requests/preview/767928?fromList=true | |
| 3 | 783749008 | Conventional release oral ointment (dose form) | Not Referenced | Inactivation target is 1217289009 |Conventional release oromucosal ointment (dose form)| that was added based on a request from François Macary referencing EDQM PDF mapping; e-prescribe; e-dispense: https://request.ihtsdotools.org/#/requests/preview/767927?fromList=true | |
| 4 | 1231841006 | Porous impregnated material for conventional release vapor inhalation (dose form) | Referenced | Pending | Mapped to EDQM: 50033100 Inhalation vapour, impregnated plug Historical associations to active concepts:
Christopher Jarvis Inhalation implies pulmonary, favors replacing by 1269278009 |Porous impregnated material for conventional release pulmonary vapor inhalation (dose form)| EDQM Interested in understanding the product with more detail. Ian Spiers The source materials defined that there was oromucosal use in nicotine cartridges. Original request from Sweden. https://www.medicines.org.uk/emc/product/4707/smpc#gref "Nicorette 15mg Inhalator: inhalation cartridge for oromucosal use" Nicola Ingram Request was from Ireland SPC http://www.hpra.ie/img/uploaded/swedocuments/Licence_PA0330-037-010_31072023145601.pdf page 3 "The patient may find deep drawing or short sucks on the mouthpiece most effective – patients soon find a favoured technique. Nicotine vapour passing through the mouth is absorbed by the buccal mucosa: little reaches the lungs." Problem was that 1231841006 |Porous impregnated material for conventional release vapor inhalation (dose form)| was pulmonary dose form. Inactivation reason for Porous impregnated material for conventional release vapor inhalation (dose form) may be incorrect (did not add corresponding clinical drug as failed release validation check). Julie M. James respiratory track does not include oromucosal. Guillermo Reynoso why is the inactivation reason Outdated? Maybe an option is to maintain the more general concept and add the new ones as childrenUnder discussion |
| 5 | 784575004 | Conventional release oral spray (dose form) | Not Referenced | Unsure why Toni inactivated but new concept requested by François Macary 1229934008 |Conventional release emulsion for oromucosal spray (dose form)| https://request.ihtsdotools.org/#/requests/preview/769485?fromList=true | |
| 6 | 784576003 | Prolonged-release intrauterine drug delivery system (dose form) | Not Referenced | https://request.ihtsdotools.org/#/requests/preview/769521?fromList=true request from François Macary Hi François, Due to the types of changes being requested, the existing concept will be inactivated and replaced with a new concept instead of being updated. Kind regards, |
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