Page History

763158003 |Medicinal product (product)

900000000000073002 |Sufficiently defined by necessary conditions definition status (core metadata concept)|

• Exceptions:
  • Concepts with product strength that is "not equal to" (e.g. with product strength expressed as a range, greater than, or less than) will have definition status 900000000000074008 |Necessary but not sufficient concept definition status (core metadata concept)

Range: 736542009 |Pharmaceutical dose form (dose form)

• • • NOTE: While the allowed range for this attribute is broader, the CD-precise continuous dose from concepts should only use descendants of 736542009 | Pharmaceutical dose form (dose form), excluding grouper concepts based on intended site (e.g. 740596000 |Cutaneous dose form (dose form)|, 385268001 |Oral dose form (dose form)|)

Cardinality: 1..1

The attribute value should represent the manufactured dose form

Notes:

• Concepts with dose form of drops will be modeled in the International Release with general Pharmaceutical dose form concepts (e.g. 385018001 |Conventional release oral drops (dose form)|).
  • • More specific Pharmaceutical dose form concepts (e.g. 385019009 |Conventional release solution for oral drops (dose form)|) will be available for use to model content in national extensions.
• Powder and granules for oral suspension, solution, etc. may be modeled using concentration strength and the administrable dose form (e.g. 1145409004 |Product containing precisely amoxicillin 25 milligram/1 milliliter and clavulanic acid (as clavulanate potassium) 6.25 milligram/1 milliliter conventional release oral suspension (clinical drug)|)

Concrete Type: Integer

Range: >#0..

Cardinality: 1..1

Range: 105590001 |Substance (substance) - descendants only, excluding concepts representing structural groupers, dispositions, or combined substances

Cardinality: 1..1 per relationship group

Notes:

• The PAI cannot be modeled as a substance hydrate or solvate unless the BoSS is expressed as a hydrate or solvate.
• Concepts containing pancreatic enzymes will be modeled based on the discrete enzymes; because of variability between real clinical drugs, synonyms representing a total amount in a particular product will not be included in the International Release.

Range: 105590001 |Substance (substance) - descendants only, excluding concepts representing structural groupers, dispositions, or combined substances

Cardinality: 1..1 per relationship group

Concrete Type: Decimal

Range: >#0..

Cardinality: 1..1 per relationship group

Expression of product strength in metric units is preferred.

To avoid semantically equivalent concepts, product strength for metric units are normalized as follows:

• Use milligram if value is <1000; if > then convert to gram
• Use microgram if value is <1000; if > then convert to milligram
• Use nanogram if value is <1000; if > then convert to microgram
  
• Use picogram if value is <1000; if > then convert to nanogram

To avoid semantically equivalent concepts, product strength for units are normalized as follows:

• Use million unit if value is >1000000 unit

The following units are not allowed unless specifically noted as an exception:

• 408165007 |Mega u (qualifier value)|

Repeating decimals are rounded to three decimal places (with 5 and above rounded up and 4 and below rounded down).

Range: 767524001 |Unit of measure (qualifier value)| - descendants only

Cardinality: 1..1 per relationship group

Concrete Type: Decimal

Range: >#0..

Cardinality: 1..1 per relationship group

For this pattern the attribute value must be 38112003 |1 (qualifier value)|

Note: the denominator strength value is required for concepts in the International Release even though the value = 1 because including denominators for only some concepts negatively affects the classification results.