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Scott Campbell Nicola Ingram

1. Colon - This model holds for colon.  Some discussion of the use of characterizes = metastatic  discontinuous spread, but general agreement reached that this term both suffices and is accurate.

2. Melanoma (microsatellite) - Definition needs to stay primitive as definition of discontinuous spread from one part of the skin to another part of the skin structure AND within 2 cm cannot be modelled with necessary and sufficient conditions

diagram-1178984009.png

Scott Campbell

1. Presence of tumor buds - growth process << budding  
   
   Process could be defined as "budding" and included in the proliferation process qualifiers.  Then this could be considered sufficiently defined.  For now, concept will be left primitive
2. diagram-1217526001.png
   
   
   
3. Number of tumor buds.  This concept must be left primitive for now as there is no way to describe a tumor bud which consists of 1-4 cells at the leading edge of the invasive neoplasm.  
   diagram-1217527005.png

Jim Case

Scott Campbell

Scott Campbell