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The "containing Medicinal Product" (MP containing) concept is defined by a single attribute:
| Semantic tag | (medicinal product) |
| Definition status | | Concept |
|---|
| t | 900000000000073002 |Sufficiently defined concept definition status |
|---|
|
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(core metadata concept): none Attribute: Has active ingredient | Range: 105590001|Substance (substance) - descendants only, excluding | Role Group | Attribute | Scg expression |
|---|
127489000 |Has active ingredient| |
| Range
| Scg expression |
|---|
< 105590001|Substance| |
Excluding concepts representing structural groupers, dispositions, or combined substances
Cardinality |
: - there Notes - There is no technical limit on the number of
| Concept |
|---|
| ShowParts | term |
|---|
| t | 127489000 |Has active ingredient| |
|---|
|
attributes that may be added to a concept; a practical limit may be imposed at a later date - For content in the International Release, this attribute value should represent the base ingredient, not a modification, unless explicitly identified as an exception.
This attribute describes the set of active ingredient substances that the concept minimally contains. A set set of active ingredient substances may well have only one member. |
Use case(s) supported by MP (containing)
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The " Medicinal Product containing only" (MP only) concept is defined by two attributes describing the active ingredient(s) and the ingredient count:
| Semantic tag | (medicinal product) |
| Definition status | | Concept |
|---|
| t | 900000000000073002 |Sufficiently defined concept definition status |
|---|
|
|
(core metadata concept): none identified:Has active ingredient
Range: 105590001|Substance (substance) | Scg expression |
|---|
127489000 |Has active ingredient| |
| Range Range: | Scg expression |
|---|
| < 105590001|Substance| |
- descendants only, excluding concepts representing structural groupers, dispositions, or combined substances - Excluding concepts representing structural groupers, dispositions, or combined substances
Cardinality |
: - there Notes - There is no technical limit on the number
|
of Cardinality: - of
| Concept |
|---|
| ShowParts | term |
|---|
| t | 127489000 |Has active ingredient| |
|---|
|
attributes that may be added to a concept; a practical limit may be imposed at a later date - This attribute describes the set of active ingredient substances that the concept minimally contains. A set set of active ingredient substances may well have only one member
|
|
:Count of base of active ingredient
Range: 260299005|Number (qualifier value)| - descendants only| Scg expression |
|---|
1142139005 |Count of base of active ingredient| |
| Range Cardinality |
Notes - This attribute provides the number of base active ingredient substances present in the medicinal product
|
Use case(s) supported by MP (only)
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Note that, in IDMP, for products using adjuvants it is probable that the adjuvant would be included as part of the "active substance set" and its role explicitly identified. For example aluminium hydroxide is used as an adjuvant in several vaccine products (e.g. hepatitis A, hepatitis B) in addition to the antigen itself to enhance the immune response; it is not an active ingredient per se and it is not an inactive ingredient, it is explicitly an "adjuvant". However, this type of detail of the implementation of the abstract model of ISO 11616 remains unclear, and in its first implementation, vaccines are out of scope for the Medicinal Product hierarchy model in SNOMED CT.
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Medicinal Product (MP precisely) (closed world view) - optional concept class - not populated in the International Release
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Definition of MP (precisely)
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For further details, see the Ingredient Count sectionattributes below.
Attributes of MP (precisely)
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In national extensions using the MP precisely concept where there is no MP precisely concept in the international and CD concepts do not have multiple ingredient counts so that classification results are not as expected, it may be necessary to override the international definition of some concepts in the sub-hierarchy in the national extension (e.g. if a CD containing one of the precise ingredient substances has only one count attribute in the international, but requires two or three count attributes in the national in order to get correct classification into an MP precisely concept).
| Semantic tag | (medicinal product) |
| Definition status | | Concept |
|---|
| t | 900000000000073002 |Sufficiently defined concept definition status |
|---|
|
|
(core metadata concept): none identifiedHas precise active ingredient
Range: < 105590001|Substance (substance)|Cardinality: :| Scg expression |
|---|
762949000 |Has precise active ingredient| |
| Range
| Scg expression |
|---|
< 105590001|Substance| |
- Excluding concepts representing structural groupers, dispositions, or combined substances
Cardinality |
Cardinality: Notes - This is the set of precise active ingredient substances that the medicinal product contains. A set of precise active ingredient substances may have only one member
|
|
:Count of base of active ingredient
Range: 260299005|Number (qualifier value)| - descendants only| Scg expression |
|---|
1142139005 |Count of base of active ingredient| |
| Range Cardinality |
Count of base and modification pair
Range: 260299005|Number (qualifier value)| - descendants onlyCardinality: Notes - This attribute provides the number of base active ingredient substances present in the medicinal product
|
|
:| Scg expression |
|---|
1142141006 |Count of base and modification pair| |
| Range Cardinality |
Count of active ingredient
Range: 260299005|Number (qualifier value)| - descendants onlyCardinality: Notes - This attribute provides the number of base active ingredient substances present in the medicinal product
- This attribute should only be present and valued for multi-ingredient product concepts where two or more active ingredients are share the same base active ingredient (i.e. parent ingredient substance) and for single ingredient product concepts where the active substance is an ingredient in multi-ingredient products. As discussed above, and as described in the MRCM rules, the additional ingredient count attributes have to be applied iteratively
|
|
:| Scg expression |
|---|
1142140007 |Count of active ingredient| |
| Range Cardinality |
Notes - This attribute provides the number of active ingredients present in the medicinal product
- This attribute should only be present and valued for multi-ingredient concepts where two or more active ingredients are share the same base active ingredient (i.e. parent ingredient substance) and where one is a further modification of the other (for example, a multi-ingredient product containing both dexamethasone phosphate and dexamethasone sodium phosphate, where the dexamethasone phosphate is a modification of dexamethasone (base) and dexamethasone sodium phosphate is a further modification of the dexamethasone phosphate), and for single ingredient product concepts where the active substance is an ingredient in multi-ingredient products. As discussed above, and as described in the MRCM rules, the additional ingredient count attributes have to be applied iteratively.
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Use case(s) supported by MP (precisely)
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This class will not form part of the medicinal product content provided in the international release. National extensions may require this subclass for certain use cases for particular types of products, as described above.
The MP (precisely) concept may also be directly compatible with the ISO 11616 concept of a level 1 Pharmaceutical Product (PhPID_SUB_L1), especially if the "active substance set" is likely to be described including all modifications. However, since SNOMED CT model use cases suggest that MP (precisely) concepts are created only when different modifications of the base active ingredient have clinical significance, the number of MP (precisely) concepts that will exist in SNOMED CT is likely to be far less than the number of PhPID_SUB_L1 concepts.
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